Anti-atopic dermatitis effect of a modified Huang-Lian-Jie-Du decoction and its active fraction on 2,4-dinitrobenzene and MC903-induced mouse models.

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Abstract

Huang-Lian-Jie-Du Decoction is a traditional Chinese medicine formula which has long been used to treat inflammatory skin disease including AD. However, Gardeniae Fructus, a component herb of HLJDD, has noticeable toxicity in liver and kidney. We therefore replaced Gardeniae Fructus with Dictamni Cortex with a hope to derive at a modified HLJDD (MHLJDD) with better safety profile.

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Journal

Journal ID (iso-abbrev): Phytomedicine

Title: Phytomedicine : international journal of phytotherapy and phytopharmacology

Publisher: Elsevier BV

ISSN (Electronic): 1618-095X

ISSN (Print): 0944-7113

Publication date (Electronic): Sep 2022

Volume: 104

Affiliations

[1 ] School of Chinese Medicine, Faculty of Medicine, The Chinese University of Hong Kong, Room 101-J, 1/F, Li Wai Chun Building, Shatin, NT, China Hong Kong Special Administrative Region.

[2 ] School of Chinese Medicine, Faculty of Medicine, The Chinese University of Hong Kong, Room 101-J, 1/F, Li Wai Chun Building, Shatin, NT, China Hong Kong Special Administrative Region; Hong Kong Institute of Integrative Medicine, The Chinese University of Hong Kong, China Hong Kong Special Administrative Region.

[3 ] School of Chinese Medicine, Faculty of Medicine, The Chinese University of Hong Kong, Room 101-J, 1/F, Li Wai Chun Building, Shatin, NT, China Hong Kong Special Administrative Region. Electronic address: lisaxian@cuhk.edu.hk.

[4 ] School of Chinese Medicine, Faculty of Medicine, The Chinese University of Hong Kong, Room 101-J, 1/F, Li Wai Chun Building, Shatin, NT, China Hong Kong Special Administrative Region; Hong Kong Institute of Integrative Medicine, The Chinese University of Hong Kong, China Hong Kong Special Administrative Region; Li Dak Sum Yip Yio Chin R&D Centre for Chinese Medicine, The Chinese University of Hong Kong, China Hong Kong Special Administrative Region. Electronic address: linzx@cuhk.edu.hk.

Article

Publisher Item ID: S0944-7113(22)00425-1

DOI: 10.1016/j.phymed.2022.154346

PubMed ID: 35872445

SO-VID: 7371e614-2414-42e8-bdf3-46e7ac24ed1a

History

Keywords: DNCB-sensitized mouse,NF-κB and MAPK pathways,Modified Huang-Lian-Jie-Du decoction,MC903-sensitized mouse,Gut microbiota,Atopic dermatitis

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Keywords: DNCB-sensitized mouse, NF-κB and MAPK pathways, Modified Huang-Lian-Jie-Du decoction, MC903-sensitized mouse, Gut microbiota, Atopic dermatitis

Anti-atopic dermatitis effect of a modified Huang-Lian-Jie-Du decoction and its active fraction on 2,4-dinitrobenzene and MC903-induced mouse models.

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Abstract

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Karger: Dermatology

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