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      Involvement of Extracellularly Bound Calcium in the Activation of Arterial Smooth Muscle

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          Abstract

          The role of extracellularly bound Ca in the activation of rabbit aorta by the PGH<sub>2 </sub>analogue U-44069 was assessed using <sup>45</sup>Ca flux determinations. The <sup>45</sup>Ca influx process, which is activated by U-44069, was found to exhibit two phases: an initial rapid phase which was transient and a slower phase which was sustained. The <sup>45</sup>Ca-<sup>40</sup>Ca exchange labeling rate of the Ca pool which enters the cell during the initial phase of Ca influx was found to be much slower than that of the free extracellular Ca<sup>2+</sup>, but quite similar to that of an extracellularly bound Ca pool. These findings suggest that an extracellularly bound Ca pool, possibly located on the outer surface of the plasmalemma, is involved in the U-44069-stimulated Ca influx process.

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          Author and article information

          Journal
          JVR
          J Vasc Res
          10.1159/issn.1018-1172
          Journal of Vascular Research
          S. Karger AG
          1018-1172
          1423-0135
          1983
          1983
          19 September 2008
          : 20
          : 6
          : 295-305
          Affiliations
          Department of Pharmacology, University of Miami School of Medicine, Miami, Fla., USA
          Article
          158483 Blood Vessels 1983;20:295–305
          10.1159/000158483
          © 1983 S. Karger AG, Basel

          Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

          Page count
          Pages: 11
          Categories
          Research Paper

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