Involvement of Extracellularly Bound Calcium in the Activation of Arterial Smooth Muscle

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Abstract

The role of extracellularly bound Ca in the activation of rabbit aorta by the PGH2 analogue U-44069 was assessed using 45Ca flux determinations. The 45Ca influx process, which is activated by U-44069, was found to exhibit two phases: an initial rapid phase which was transient and a slower phase which was sustained. The 45Ca-40Ca exchange labeling rate of the Ca pool which enters the cell during the initial phase of Ca influx was found to be much slower than that of the free extracellular Ca2+, but quite similar to that of an extracellularly bound Ca pool. These findings suggest that an extracellularly bound Ca pool, possibly located on the outer surface of the plasmalemma, is involved in the U-44069-stimulated Ca influx process.

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Journal

Journal ID (publisher-id): JVR

Journal ID (nlm-ta): J Vasc Res

Journal ID (doi): 10.1159/issn.1018-1172

Title: Journal of Vascular Research

Publisher: S. Karger AG

ISSN (Print): 1018-1172

ISSN (Electronic): 1423-0135

Publication date Subscription-year: 1983

Publication date (Print): 1983

Publication date (Electronic): 19 September 2008

Volume: 20

Issue: 6

Pages: 295-305

Affiliations

Department of Pharmacology, University of Miami School of Medicine, Miami, Fla., USA

Article

Publisher ID: 158483 Other ID: Blood Vessels 1983;20:295–305

DOI: 10.1159/000158483

SO-VID: 74c26fb4-a79e-48b5-9541-e513c95d1993

License:

Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

History

Date received : 25 October 1982

Date accepted : 28 February 1983

Page count

Pages: 11

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