Extracellular Vesicles in Bile as Markers of Malignant Biliary Stenoses.

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Abstract

Algorithms for diagnosis of malignant common bile duct (CBD) stenoses are complex and lack accuracy. Malignant tumors secrete large numbers of extracellular vesicles (EVs) into surrounding fluids; EVs might therefore serve as biomarkers for diagnosis. We investigated whether concentrations of EVs in bile could discriminate malignant from nonmalignant CBD stenoses.

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Author and article information

Journal

Journal ID (iso-abbrev): Gastroenterology

Title: Gastroenterology

Publisher: Elsevier BV

ISSN (Electronic): 1528-0012

ISSN (Print): 0016-5085

Publication date (Electronic): May 04 2017

Affiliations

[1 ] Department of Internal Medicine Specialties, University of Geneva, Geneva, Switzerland; Department of Human Protein Science, University of Geneva, Geneva, Switzerland.

[2 ] Gedyt Endoscopy Center, Buenos Aires, Argentina.

[3 ] Department of Gastroenterology, Hepatopancreatology and GI Oncology, Erasme University Hospital, Brussels, Belgium.

[4 ] Department of Pathology, University Hospitals of Geneva, Geneva, Switzerland.

[5 ] Department of Human Protein Science, University of Geneva, Geneva, Switzerland.

[6 ] Biotech Research and Innovation Center, University of Copenhagen, Copenhagen, Denmark.

[7 ] Department of Internal Medicine Specialties, University of Geneva, Geneva, Switzerland; Service of Gastroenterology and Hepatology, University Hospitals of Geneva, Switzerland. Electronic address: Jean-Louis.Frossard@hcuge.ch.

[8 ] Department of Internal Medicine Specialties, University of Geneva, Geneva, Switzerland; Department of Human Protein Science, University of Geneva, Geneva, Switzerland. Electronic address: Annarita.Farina@unige.ch.

Article

Publisher Item ID: S0016-5085(17)35553-1

DOI: 10.1053/j.gastro.2017.04.043

PubMed ID: 28479376

SO-VID: 750d1137-d09b-43be-8a5d-f81e020598eb

History

Keywords: Biliary strictures,Exosomes,Microparticles,Microvesicles

Data availability:

Keywords: Biliary strictures, Exosomes, Microparticles, Microvesicles

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