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      Exploration versus exploitation in space, mind, and society.

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          Abstract

          Search is a ubiquitous property of life. Although diverse domains have worked on search problems largely in isolation, recent trends across disciplines indicate that the formal properties of these problems share similar structures and, often, similar solutions. Moreover, internal search (e.g., memory search) shows similar characteristics to external search (e.g., spatial foraging), including shared neural mechanisms consistent with a common evolutionary origin across species. Search problems and their solutions also scale from individuals to societies, underlying and constraining problem solving, memory, information search, and scientific and cultural innovation. In summary, search represents a core feature of cognition, with a vast influence on its evolution and processes across contexts and requiring input from multiple domains to understand its implications and scope.

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          Cellular basis of working memory

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            Inverted-U-shaped dopamine actions on human working memory and cognitive control.

            Brain dopamine (DA) has long been implicated in cognitive control processes, including working memory. However, the precise role of DA in cognition is not well-understood, partly because there is large variability in the response to dopaminergic drugs both across different behaviors and across different individuals. We review evidence from a series of studies with experimental animals, healthy humans, and patients with Parkinson's disease, which highlight two important factors that contribute to this large variability. First, the existence of an optimum DA level for cognitive function implicates the need to take into account baseline levels of DA when isolating the effects of DA. Second, cognitive control is a multifactorial phenomenon, requiring a dynamic balance between cognitive stability and cognitive flexibility. These distinct components might implicate the prefrontal cortex and the striatum, respectively. Manipulating DA will thus have paradoxical consequences for distinct cognitive control processes, depending on distinct basal or optimal levels of DA in different brain regions. Copyright © 2011 Society of Biological Psychiatry. Published by Elsevier Inc. All rights reserved.
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              Patients with hippocampal amnesia cannot imagine new experiences.

              Amnesic patients have a well established deficit in remembering their past experiences. Surprisingly, however, the question as to whether such patients can imagine new experiences has not been formally addressed to our knowledge. We tested whether a group of amnesic patients with primary damage to the hippocampus bilaterally could construct new imagined experiences in response to short verbal cues that outlined a range of simple commonplace scenarios. Our results revealed that patients were markedly impaired relative to matched control subjects at imagining new experiences. Moreover, we identified a possible source for this deficit. The patients' imagined experiences lacked spatial coherence, consisting instead of fragmented images in the absence of a holistic representation of the environmental setting. The hippocampus, therefore, may make a critical contribution to the creation of new experiences by providing the spatial context into which the disparate elements of an experience can be bound. Given how closely imagined experiences match episodic memories, the absence of this function mediated by the hippocampus, may also fundamentally affect the ability to vividly re-experience the past.
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                Author and article information

                Journal
                Trends Cogn. Sci. (Regul. Ed.)
                Trends in cognitive sciences
                1879-307X
                1364-6613
                Jan 2015
                : 19
                : 1
                Affiliations
                [1 ] Department of Psychology, University of Warwick, Coventry, UK. Electronic address: t.t.hills@warwick.ac.uk.
                [2 ] Cognitive Science Program, Indiana University, Bloomington, IN, USA.
                [3 ] Department of Political Science, Northeastern University, Boston, MA, USA; College of Computer and Information Science, Northeastern University, Boston, MA, USA; Harvard Kennedy School, Harvard University, Cambridge, MA, USA.
                [4 ] Department of Neuroscience, University of Minnesota, Minneapolis, MN, USA.
                [5 ] Department of Ecology and Evolutionary Biology, Princeton University, Princeton, NJ, USA; Department of Collective Behaviour, Max Planck Institute of Ornithology, Konstanz, Germany.
                Article
                S1364-6613(14)00233-2 NIHMS680820
                10.1016/j.tics.2014.10.004
                4410143
                25487706
                7536da3b-d4e0-452c-862a-29c3897aedcd
                Copyright © 2014 Elsevier Ltd. All rights reserved.
                History

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