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      Early onset of reproductive function in normal female mice treated with leptin.

      Science (New York, N.Y.)

      Animals, Body Weight, drug effects, Eating, Estradiol, blood, Estrus, Female, Genitalia, Female, Leptin, Luteinizing Hormone, Mice, Mice, Inbred C57BL, Organ Size, Proteins, analysis, pharmacology, Recombinant Proteins, Reproduction, Sexual Maturation

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          Abstract

          Numerous studies have revealed an association between nutritional status, adiposity, and reproductive maturity. The role of leptin, a hormone secreted from adipose tissue, in the onset of reproductive function was investigated. Normal prepubertal female mice injected with leptin grew at a slower rate than controls as a result of the hormone's thinning effects, but they reproduced up to 9 days earlier than controls and showed earlier maturation of the reproductive tract. These results suggest that leptin acts as a signal triggering puberty, thus supporting the hypothesis that fat accumulation enhances maturation of the reproductive tract.

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          8974400

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