Sera of IgA Nephropathy Patients Contain a Heterogeneous Population of Relatively Cationic Alpha-Heavy Chains

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Abstract

Sera of IgA nephropathy (IgAN) patients and normal subjects were analysed by two-dimensional (2-D) gel electrophoresis. Densitometric analysis of the 2-D gels of IgAN patients and normal subjects revealed that their protein maps were comparable. There was no shift of pI values in the major α-heavy chain spots. However, the volume of the α-heavy chain bands were differently distributed. Distribution was significantly lower at the anionic region in IgAN patients (mean anionic:cationic ratio of 1.184 ± 0.311) as compared to normal healthy controls (mean anionic:cationic ratio of 2.139 ± 0.538). Our data are in support of the previously reported findings that IgA1 of IgAN patients were lacking in sialic acid residues.

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Iga binding lectins isolated from distinct artocarpus species demonstrate differential specificity

Onn Hashim, Chee Liang Ng, Gurmil Singh Gendeh … (1991)

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Author and article information

Journal

Journal ID (publisher-id): NEF

Journal ID (nlm-ta): Nephron

Journal ID (doi): 10.1159/issn.1660-8151

Title: Nephron

Publisher: S. Karger AG

ISSN (Print): 1660-8151

ISSN (Electronic): 2235-3186

Publication date Subscription-year: 1998

Publication date (Print): March 1998

Publication date (Electronic): 25 February 1998

Volume: 78

Issue: 3

Pages: 290-295

Affiliations

Departments of ^a Biochemistry and ^b Medicine, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia

Article

Publisher ID: 44938 Other ID: Nephron 1998;78:290–295

DOI: 10.1159/000044938

PubMed ID: 9546689

SO-VID: 7817e396-6eaa-4b25-be86-3143739fc154

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