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      Sera of IgA Nephropathy Patients Contain a Heterogeneous Population of Relatively Cationic Alpha-Heavy Chains

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      a , b , a
      Nephron
      S. Karger AG
      IgA nephropathy, α-Heavy chain, Two-dimensional electrophoresis

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          Abstract

          Sera of IgA nephropathy (IgAN) patients and normal subjects were analysed by two-dimensional (2-D) gel electrophoresis. Densitometric analysis of the 2-D gels of IgAN patients and normal subjects revealed that their protein maps were comparable. There was no shift of pI values in the major α-heavy chain spots. However, the volume of the α-heavy chain bands were differently distributed. Distribution was significantly lower at the anionic region in IgAN patients (mean anionic:cationic ratio of 1.184 ± 0.311) as compared to normal healthy controls (mean anionic:cationic ratio of 2.139 ± 0.538). Our data are in support of the previously reported findings that IgA1 of IgAN patients were lacking in sialic acid residues.

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          Iga binding lectins isolated from distinct artocarpus species demonstrate differential specificity

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            Author and article information

            Journal
            NEF
            Nephron
            10.1159/issn.1660-8151
            Nephron
            S. Karger AG
            1660-8151
            2235-3186
            1998
            March 1998
            25 February 1998
            : 78
            : 3
            : 290-295
            Affiliations
            Departments of a Biochemistry and b Medicine, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia
            Article
            44938 Nephron 1998;78:290–295
            10.1159/000044938
            9546689
            7817e396-6eaa-4b25-be86-3143739fc154
            © 1998 S. Karger AG, Basel

            Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

            History
            Page count
            Figures: 5, References: 19, Pages: 6
            Categories
            Original Paper

            Cardiovascular Medicine,Nephrology
            IgA nephropathy,α-Heavy chain,Two-dimensional electrophoresis

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