Childhood adversity and borderline personality disorder: a meta‐analysis

There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

Abstract

The aim of this meta-analysis was to better understand the magnitude and consistency of the association between childhood adversity and borderline personality disorder (BPD) across case-control, epidemiological and prospective cohort studies.

Related collections

Most cited references 116

Record: found
Abstract: found
Article: not found

Childhood maltreatment and characteristics of adult depression: meta-analysis.

Janna Nelson, Anne Klumparendt, Philipp Doebler … (2017)

Childhood maltreatment has been discussed as a risk factor for the development and maintenance of depression.

0 comments Cited 218 times – based on 0 reviews      Review now

Bookmark

Record: found
Abstract: found
Article: found

Is Open Access

Adverse Childhood Experiences and the Consequences on Neurobiological, Psychosocial, and Somatic Conditions Across the Lifespan

Julia I Herzog, Christian Schmahl (2018)

Introduction: Adverse childhood experiences (ACE) such as sexual and physical abuse or neglect are frequent in childhood and constitute a massive stressor with long-lasting adverse effects on the brain, mental and physical health.The aim of this qualitative review is to present a concise overview of the present literature on the impact of ACE on neurobiology, mental and somatic health in later adulthood. Methods: The authors reviewed the existing literature on the impact of ACE on neurobiology, mental and somatic health in later adulthood and summarized the results for a concise qualitative overview. Results: In adulthood, the history of ACE can result in complex clinical profiles with several co-occurring mental and somatic disorders such as posttraumatic stress disorder, depression, borderline personality disorder, obesity and diabetes. Although a general stress effect in the development of the disorders and neural alterations can be assumed, the role of type and timing of ACE is of particular interest in terms of prevention and treatment of ACE-related mental and somatic conditions. It has been suggested that during certain vulnerable developmental phases the risk for subsequent ACE-related disorders is increased. Moreover, emerging evidence points to sensitive periods and specificity of ACE-subtypes in the development of neurobiological alterations, e.g., volumetric and functional changes in the amygdala and hippocampus. Conclusion: Longitudinal studies are needed to investigate complex ACE-related characteristics and mechanisms relevant for mental and somatic disorders by integrating state of the art knowledge and methods. By identifying and validating psychosocial and somatic risk factors and diagnostic markers one might improve the development of innovative somatic and psychological treatment options for individuals suffering from ACE-related disorders.

0 comments Cited 136 times – based on 0 reviews      Review now

Bookmark

Record: found
Abstract: found
Article: not found

Childhood trauma in borderline personality disorder.

J. Herman, J Perry, B van der Kolk (1989)

Subjects with borderline personality disorder (N = 21) or borderline traits (N = 11) and nonborderline subjects with closely related diagnoses (N = 23) were interviewed in depth regarding experiences of major childhood trauma. Significantly more borderline subjects (81%) gave histories of such trauma, including physical abuse (71%), sexual abuse (68%), and witnessing serious domestic violence (62%); abuse histories were less common in those with borderline traits and least common in the subjects with no borderline diagnosis. These results demonstrate a strong association between a diagnosis of borderline personality disorder and a history of abuse in childhood.

0 comments Cited 104 times – based on 0 reviews      Review now

Bookmark

All references

Author and article information

Journal

Title: Acta Psychiatrica Scandinavica

Abbreviated Title: Acta Psychiatr Scand

Publisher: Wiley

ISSN (Print): 0001-690X

ISSN (Electronic): 1600-0447

Publication date Created: November 18 2019

Publication date (Electronic): November 18 2019

Affiliations

[1 ]Division of Psychology and Mental Health Faculty of Biology, Medicine and Health The University of Manchester Manchester UK

[2 ]Spectrum Centre for Mental Health Research Division of Health Research Lancaster University Lancaster UK

[3 ]Lancashire Care NHS Foundation Trust Lancashire UK

[4 ]Complex Trauma and Resilience Research Unit Greater Manchester Mental Health NHS Foundation Trust Manchester Academic Health Science Centre Manchester UK