Obstructive sleep apneas naturally occur in mice during REM sleep and are highly prevalent in a mouse model of Down syndrome.

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Abstract

The use of mouse models in sleep apnea study is limited by the belief that central (CSA) but not obstructive sleep apneas (OSA) occur in rodents. We aimed to develop a protocol to investigate the presence of OSAs in wild-type mice and, then, to apply it to a validated model of Down syndrome (Ts65Dn), a human pathology characterized by a high incidence of OSAs.

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Author and article information

Journal

Journal ID (iso-abbrev): Neurobiol Dis

Title: Neurobiology of disease

Publisher: Elsevier BV

ISSN (Electronic): 1095-953X

ISSN (Print): 0969-9961

Publication date (Electronic): Nov 2021

Volume: 159

Affiliations

[1 ] Section of Orthodontics, Department of Biomedical and Neuromotor Sciences, Alma Mater Studiorum - University of Bologna, Bologna, Italy; PRISM Lab, Department of Biomedical and Neuromotor Sciences, Alma Mater Studiorum - University of Bologna, Bologna, Italy.

[2 ] PRISM Lab, Department of Biomedical and Neuromotor Sciences, Alma Mater Studiorum - University of Bologna, Bologna, Italy.

[3 ] Department of Biomedical and Neuromotor Sciences, Alma Mater Studiorum - University of Bologna, Bologna, Italy.

[4 ] Department for Life Quality Studies, University of Bologna, Rimini, Italy.

[5 ] Sleep Disorder Center, Villa Igea-Ospedali Privati Forlì, Forlì, Italy.

[6 ] Section of Orthodontics, Department of Biomedical and Neuromotor Sciences, Alma Mater Studiorum - University of Bologna, Bologna, Italy.

[7 ] PRISM Lab, Department of Biomedical and Neuromotor Sciences, Alma Mater Studiorum - University of Bologna, Bologna, Italy. Electronic address: giovanna.zoccoli@unibo.it.

Article

Publisher Item ID: S0969-9961(21)00257-6

DOI: 10.1016/j.nbd.2021.105508

PubMed ID: 34509609

SO-VID: 79aa9f26-f0f8-47d3-a8c2-602cc50bf734

History

Keywords: Mice,Respiratory disorder,Apneas,Breathing,Down syndrome

Data availability:

Keywords: Mice, Respiratory disorder, Apneas, Breathing, Down syndrome

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