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Structural DNA Nanotechnology: State of the Art and Future Perspective

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      Over the past three decades DNA has emerged as an exceptional molecular building block for nanoconstruction due to its predictable conformation and programmable intra- and intermolecular Watson–Crick base-pairing interactions. A variety of convenient design rules and reliable assembly methods have been developed to engineer DNA nanostructures of increasing complexity. The ability to create designer DNA architectures with accurate spatial control has allowed researchers to explore novel applications in many directions, such as directed material assembly, structural biology, biocatalysis, DNA computing, nanorobotics, disease diagnosis, and drug delivery. This Perspective discusses the state of the art in the field of structural DNA nanotechnology and presents some of the challenges and opportunities that exist in DNA-based molecular design and programming.

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      Most cited references 120

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            Author and article information

            Center for Molecular Design and Biomimicry, Biodesign Institute, and Department of Chemistry and Biochemistry, Arizona State University , Tempe, Arizona 85287, United States
            Author notes
            J Am Chem Soc
            J. Am. Chem. Soc
            Journal of the American Chemical Society
            American Chemical Society
            16 July 2015
            16 July 2014
            13 August 2014
            : 136
            : 32
            : 11198-11211
            25029570 4140475 10.1021/ja505101a
            Copyright © 2014 American Chemical Society

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            National Institutes of Health, United States
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