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      Effects of neuromyelitis optica-IgG at the blood-brain barrier in vitro.

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      Journal: Neurology(R) neuroimmunology & neuroinflammation
      Publisher: Ovid Technologies (Wolters Kluwer Health)

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          Abstract

          To address the hypothesis that physiologic interactions between astrocytes and endothelial cells (EC) at the blood-brain barrier (BBB) are afflicted by pathogenic inflammatory signaling when astrocytes are exposed to aquaporin-4 (AQP4) antibodies present in the immunoglobulin G (IgG) fraction of serum from patients with neuromyelitis optica (NMO), referred to as NMO-IgG.

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          DOI:: 10.1212/NXI.0000000000000311
          PMC ID:: 5173350
          PubMed ID:: 28018943

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