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Galactomannan as a Potential Modulator of Intestinal Ischemia–Reperfusion Injury
Pablo Stringa ,
Victor Toledano ,
Rodrigo Papa-Gobbi ,
Miguel Arreola ,
Carlota Largo ,
Mariana Machuca ,
Luis A. Aguirre ,
Martin Rumbo ,
Eduardo López-Collazo ,
Francisco Hernández Oliveros
November 2019
November 2019
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Abstract
Galactomannan (GAL), a polysaccharide present on the cell wall of several fungi, has
shown an ability to modulate inflammatory responses through the dectin-1 receptor
in human macrophages. However, studies evaluating the modulatory properties of this
polysaccharide in in vivo inflammatory scenarios are scarce. We hypothesized that
GAL pretreatment would modulate local and remote damage related to intestinal reperfusion
after an ischemic insult.