Bismuth(iii) benzohydroxamates: powerful anti-bacterial activity against Helicobacter pylori and hydrolysis to a unique Bi34 oxido-cluster [Bi34O22(BHA)22(H-BHA)14(DMSO)6]

Abstract

Bismuth( iii) benzohydroxamates; [Bi ₂(HBA) ₃], [Bi( H-BHA) ₃], [Bi(HBA)( H-HBA)] and [Bi ₃₄O ₂₂(BHA) ₂₂( H-BHA) ₁₄(DMSO) ₆], all show exceptional toxicity towards Helicobacter pylori (MIC 0.08–3.24 μM).

Abstract

Reaction of BiPh 3 or Bi(O ^tBu) ₃ with benzohydroxamic acid (H ₂-BHA) results in formation of novel mono- and di-anionic hydroxamato complexes; [Bi ₂(BHA) ₃] _∞ 1, [Bi( H-BHA) ₃] 2, [Bi(BHA)( H-BHA)] 3, all of which display nM activity against Helicobacter pylori. Subsequent dissolution of [Bi ₂(BHA) ₃] _∞ in DMSO/toluene results in hydrolysis to the first structurally authenticated {Bi ₃₄} oxido-cluster [Bi ₃₄O ₂₂(BHA) ₂₂( H-BHA) ₁₄(DMSO) ₆] 4.