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      Effects of acupuncture on cartilage p38MAPK and mitochondrial pathways in animal model of knee osteoarthritis: A systematic evaluation and meta-analysis

      systematic-review

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          Abstract

          Background

          Most previous studies on acupuncture in the treatment of knee osteoarthritis (KOA) have focused on improving functional efficacy and safety, while related mechanisms have not been systematically reviewed. Acupuncture modulates cytokines to attenuate cartilage extracellular matrix degradation and apoptosis, key to the pathogenesis of KOA, but the mechanisms are complex.

          Objectives

          The purpose of this study is to assess the efficacy of acupuncture quantitatively and summarily in animal studies of KOA.

          Methods

          Nine databases including PubMed, Embase, Web of Science (including Medline), Cochrane library, Scopus, CNKI, Wan Fang, and VIP were searched to retrieve animal studies on acupuncture interventions in KOA published since the inception of the journal. Relevant literature was screened, and information extracted. Meta-analysis was performed using Revman 5.4 and Stata 17.0 software.

          Results

          The 35 included studies involved 247 animals, half of which were in acupuncture groups and half in model groups. The mean quality level was 6.7, indicating moderate quality. Meta-analysis showed that acupuncture had the following significant effects on cytokine levels in p38MAPK and mitochondrial pathways: (1) p38MAPK pathway: It significantly inhibits p38MAPK, interleukin-1beta (IL-1β), tumor necrosis factor alpha (TNF-α), phosphorylated (p)-p38MAPK, matrix metalloproteinase-13 (MMP-13), MMP-1, a disintegrin and metalloproteinase with thrombospondin motifs-5 (ADAMST-5) expression, and significantly increased the expression of collagen II and aggrecan. (2) mitochondrial pathway: It significantly inhibited the expression of Bcl-2-associated X protein (Bax), cysteine protease-3 (caspase-3), caspase-9, and Cytochrome-c (Cyt-c). And significantly increased the expression of B cell lymphocytoma-2 (Bcl-2). In addition, acupuncture significantly reduced chondrocyte apoptosis, Mankin’s score (a measure of cartilage damage), and improved cartilage morphometric characteristics.

          Conclusion

          Acupuncture may inhibit cytokine expression in the p38MAPK pathway to attenuate cartilage extracellular matrix degradation, regulate cytokines in the mitochondrial pathway to inhibit chondrocyte apoptosis, and improve cartilage tissue-related phenotypes to delay cartilage degeneration. These findings provide possible explanations for the therapeutic mechanisms and clinical benefits of acupuncture for KOA.

          Systematic review registration

          https://inplasy.com, identifier INPLASY20 2290125.

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          Most cited references69

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          OARSI guidelines for the non-surgical management of knee, hip, and polyarticular osteoarthritis

          R.R. Bannuru, M.C. Osani, E.E. Vaysbrot … (2019)
          To update and expand upon prior Osteoarthritis Research Society International (OARSI) guidelines by developing patient-focused treatment recommendations for individuals with Knee, Hip, and Polyarticular osteoarthritis (OA) that are derived from expert consensus and based on objective review of high-quality meta-analytic data.
          Article 0 comments Cited 863 times – based on 0 reviews     Review now
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            Role of proinflammatory cytokines in the pathophysiology of osteoarthritis.

            Mohit Kapoor, Johanne Martel-Pelletier, Daniel Lajeunesse … (2011)
            Osteoarthritis (OA) is associated with cartilage destruction, subchondral bone remodeling and inflammation of the synovial membrane, although the etiology and pathogenesis underlying this debilitating disease are poorly understood. Secreted inflammatory molecules, such as proinflammatory cytokines, are among the critical mediators of the disturbed processes implicated in OA pathophysiology. Interleukin (IL)-1β and tumor necrosis factor (TNF), in particular, control the degeneration of articular cartilage matrix, which makes them prime targets for therapeutic strategies. Animal studies provide support for this approach, although only a few clinical studies have investigated the efficacy of blocking these proinflammatory cytokines in the treatment of OA. Apart from IL-1β and TNF, several other cytokines including IL-6, IL-15, IL-17, IL-18, IL-21, leukemia inhibitory factor and IL-8 (a chemokine) have also been shown to be implicated in OA and could possibly be targeted therapeutically. This Review discusses the current knowledge regarding the role of proinflammatory cytokines in the pathophysiology of OA and addresses the potential of anticytokine therapy in the treatment of this disease.
            Article 0 comments Cited 521 times – based on 0 reviews     Review now
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              2019 American College of Rheumatology/Arthritis Foundation Guideline for the Management of Osteoarthritis of the Hand, Hip, and Knee

              Sharon Kolasinski, Tuhina Neogi, Marc Hochberg … (2020)
              To develop an evidence-based guideline for the comprehensive management of osteoarthritis (OA) as a collaboration between the American College of Rheumatology (ACR) and the Arthritis Foundation, updating the 2012 ACR recommendations for the management of hand, hip, and knee OA.
              Article 0 comments Cited 387 times – based on 0 reviews     Review now
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                Author and article information

                Contributors
                Journal
                Journal ID (nlm-ta): Front Neurosci
                Journal ID (iso-abbrev): Front Neurosci
                Journal ID (publisher-id): Front. Neurosci.
                Title: Frontiers in Neuroscience
                Publisher: Frontiers Media S.A.
                ISSN (Print): 1662-4548
                ISSN (Electronic): 1662-453X
                Publication date (Electronic): 11 January 2023
                Publication date Collection: 2022
                Volume: 16
                Electronic Location Identifier: 1098311
                Affiliations
                [1] 1School of Acupuncture–Moxibustion and Tuina, Chengdu University of Traditional Chinese Medicine , Chengdu, China
                [2] 2Xiyuan Hospital, China Academy of Chinese Medical Sciences , Beijing, China
                [3] 3Graduate School, Guangzhou University of Chinese Medicine , Guangzhou, China
                Author notes

                Edited by: Min Fang, Shanghai University of Traditional Chinese Medicine, China

                Reviewed by: Fan Wang, Shanghai University of Traditional Chinese Medicine, China; Cheng yong Liu, Affiliated Hospital of Nanjing University of Chinese Medicine, China

                *Correspondence: Jun Zhu, zhujuntcm@ 123456163.com

                This article was submitted to Translational Neuroscience, a section of the journal Frontiers in Neuroscience

                Article
                DOI: 10.3389/fnins.2022.1098311
                PMC ID: 9875597
                SO-VID: 7f065ec7-7e4a-48ef-9243-1c9b1a04ca52
                Copyright © Copyright © 2023 Ye, Su, Jiang, Zhou, Sun, Zheng, Miao, Li and Zhu.
                License:

                This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

                History
                Date received : 14 November 2022
                Date accepted : 13 December 2022
                Page count
                Figures: 9, Tables: 2, Equations: 0, References: 69, Pages: 18, Words: 9723
                Funding
                Funded by: National Natural Science Foundation of China, doi 10.13039/501100001809;
                Award ID: 81704152
                Award ID: 82004497
                This study was supported by the National Natural Science Foundation of China (81704152 and 82004497), and the Key Research and Development Project of Sichuan Provincial Science and Technology Department (23ZDYF1797).
                Categories
                Subject: Neuroscience
                Subject: Systematic Review

                ScienceOpen disciplines: Neurosciences
                Keywords: knee osteoarthritis,acupuncture,animal models,p38mapk pathways,mitochondrial pathways,cytokines,meta-analysis
                Data availability:
                ScienceOpen disciplines: Neurosciences
                Keywords: knee osteoarthritis, acupuncture, animal models, p38mapk pathways, mitochondrial pathways, cytokines, meta-analysis

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