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      Synergetic delivery of artesunate and isosorbide 5-mononitrate with reduction-sensitive polymer nanoparticles for ovarian cancer chemotherapy

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          Abstract

          Ovarian cancer is a highly fatal gynecologic malignancy worldwide. Chemotherapy remains the primary modality both for primary and maintenance treatments of ovarian cancer. However, the progress in developing chemotherapeutic agents for ovarian cancer has been slow in the past 20 years. Thus, new and effective chemotherapeutic drugs are urgently needed for ovarian cancer treatment. A reduction-responsive synergetic delivery strategy (PSSP@ART-ISMN) with co-delivery of artesunate and isosorbide 5-mononitrate was investigated in this research study. PSSP@ART-ISMN had various effects on tumor cells, such as (i) inducing the production of reactive oxygen species (ROS), which contributes to mitochondrial damage; (ii) providing nitric oxide and ROS for the tumor cells, which further react to generate highly toxic reactive nitrogen species (RNS) and cause DNA damage; and (iii) arresting cell cycle at the G0/G1 phase and inducing apoptosis. PSSP@ART-ISMN also demonstrated excellent antitumor activity with good biocompatibility in vivo. Taken together, the results of this work provide a potential delivery strategy for chemotherapy in ovarian cancer.

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          The online version contains supplementary material available at 10.1186/s12951-022-01676-3.

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          Cancer statistics, 2020

          Rebecca Siegel, Kimberly D Miller, Ahmedin Jemal (2020)
          Each year, the American Cancer Society estimates the numbers of new cancer cases and deaths that will occur in the United States and compiles the most recent data on population-based cancer occurrence. Incidence data (through 2016) were collected by the Surveillance, Epidemiology, and End Results Program; the National Program of Cancer Registries; and the North American Association of Central Cancer Registries. Mortality data (through 2017) were collected by the National Center for Health Statistics. In 2020, 1,806,590 new cancer cases and 606,520 cancer deaths are projected to occur in the United States. The cancer death rate rose until 1991, then fell continuously through 2017, resulting in an overall decline of 29% that translates into an estimated 2.9 million fewer cancer deaths than would have occurred if peak rates had persisted. This progress is driven by long-term declines in death rates for the 4 leading cancers (lung, colorectal, breast, prostate); however, over the past decade (2008-2017), reductions slowed for female breast and colorectal cancers, and halted for prostate cancer. In contrast, declines accelerated for lung cancer, from 3% annually during 2008 through 2013 to 5% during 2013 through 2017 in men and from 2% to almost 4% in women, spurring the largest ever single-year drop in overall cancer mortality of 2.2% from 2016 to 2017. Yet lung cancer still caused more deaths in 2017 than breast, prostate, colorectal, and brain cancers combined. Recent mortality declines were also dramatic for melanoma of the skin in the wake of US Food and Drug Administration approval of new therapies for metastatic disease, escalating to 7% annually during 2013 through 2017 from 1% during 2006 through 2010 in men and women aged 50 to 64 years and from 2% to 3% in those aged 20 to 49 years; annual declines of 5% to 6% in individuals aged 65 years and older are particularly striking because rates in this age group were increasing prior to 2013. It is also notable that long-term rapid increases in liver cancer mortality have attenuated in women and stabilized in men. In summary, slowing momentum for some cancers amenable to early detection is juxtaposed with notable gains for other common cancers.
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            Rethinking ovarian cancer II: reducing mortality from high-grade serous ovarian cancer

            David D. Bowtell, Steffen Böhm, Ahmed A. Ahmed … (2015)
            High-grade serous ovarian cancer (HGSOC) accounts for 70-80% of ovarian cancer deaths, and overall survival has not changed significantly for several decades. In this Opinion article, we outline a set of research priorities that we believe will reduce incidence and improve outcomes for women with this disease. This 'roadmap' for HGSOC was determined after extensive discussions at an Ovarian Cancer Action meeting in January 2015.
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              The discovery of artemisinin (qinghaosu) and gifts from Chinese medicine.

              Youyou Tu (2011)
              Article 0 comments Cited 213 times – based on 0 reviews     Review now
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                Author and article information

                Contributors
                Yuanling Xiao: 13622893457@163.com
                Zhiqiang Yu: yuzq@smu.edu.cn
                Xuefeng Wang: douwangxuefeng@163.com
                Journal
                Journal ID (nlm-ta): J Nanobiotechnology
                Journal ID (iso-abbrev): J Nanobiotechnology
                Title: Journal of Nanobiotechnology
                Publisher: BioMed Central (London )
                ISSN (Electronic): 1477-3155
                Publication date (Electronic): 5 November 2022
                Publication date PMC-release: 5 November 2022
                Publication date Collection: 2022
                Volume: 20
                Electronic Location Identifier: 471
                Affiliations
                [1 ]GRID grid.413107.0, Department of Obstetrics and Gynecology, , The Third Affiliated Hospital of Southern Medical University, ; Guangzhou, 510630 China
                [2 ]Southern Medical University Shenzhen Stomatology Hospital (Pingshan), Shenzhen, 518000 China
                [3 ]GRID grid.513392.f, Shenzhen Longhua District Central Hospital, ; Shenzhen, 518110 China
                [4 ]GRID grid.417404.2, ISNI 0000 0004 1771 3058, Zhujiang Hospital of Southern Medical University, ; Guangzhou, 510280 China
                [5 ]GRID grid.284723.8, ISNI 0000 0000 8877 7471, School of Pharmaceutical Sciences, Guangdong Provincial Key Laboratory of New Drug Screening, , Southern Medical University, ; Guangzhou, 510515 China
                [6 ]GRID grid.417404.2, ISNI 0000 0004 1771 3058, Department of Gynecology, Obstetrics and Gynecology Center, , Zhujiang Hospital, Southern Medical University, ; Guangzhou, 510280 China
                [7 ]GRID grid.284723.8, ISNI 0000 0000 8877 7471, Department of Laboratory Medicine, , Dongguan Institute of Clinical Cancer Research, Affiliated Dongguan Hospital, Southern Medical University, ; Dongguan, 523018 China
                Article
                Publisher ID: 1676
                DOI: 10.1186/s12951-022-01676-3
                PMC ID: 9636721
                PubMed ID: 36335352
                SO-VID: 7f84f7f8-9c30-4b46-8479-ca1c3db9d77d
                Copyright © © The Author(s) 2022
                License:

                Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver ( http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

                History
                Date received : 1 August 2022
                Date accepted : 13 October 2022
                Funding
                Funded by: Guangdong Basic and Applied Basic Research Foundation
                Award ID: No. 2114050001718
                Award Recipient :
                Funded by: Science and Technology Projects in Guangzhou
                Award ID: No. 202102080100
                Award Recipient :
                Categories
                Subject: Research
                Custom metadata
                issue-copyright-statement © The Author(s) 2022

                ScienceOpen disciplines: Biotechnology
                Keywords: artesunate,isosorbide 5-mononitrate,dna damage,mitochondrial damage,cell cycle arrest,ovarian cancer
                Data availability:
                ScienceOpen disciplines: Biotechnology
                Keywords: artesunate, isosorbide 5-mononitrate, dna damage, mitochondrial damage, cell cycle arrest, ovarian cancer

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