Journal ID (nlm-ta): PLoS One
Journal ID (iso-abbrev): PLoS ONE
Journal ID (publisher-id): plos
Journal ID (pmc): plosone
Title:
PLoS ONE
Publisher:
Public Library of Science
(San Francisco, CA USA
)
ISSN
(Electronic):
1932-6203
Publication date
(Electronic):
17
October
2016
Publication date Collection: 2016
Volume: 11
Issue: 10
Electronic Location Identifier: e0164563
Affiliations
[1
]Department of Infectious Diseases and Hepatology, Medical University of Bialystock,
Bialystock, Poland
[2
]Bon Secours Liver Institute of Virginia, Richmond, Virginia, United States of America
[3
]Department of Gastroenterology and Hepatology, University Hospital Donostia, San Sebastián,
Spain
[4
]Department of Internal Medicine, Universidade Federal do Rio Grande do Sul, Porto
Alegre, Brazil
[5
]Department of Higher Level General Medicine, Russian State Medical University, Moscow,
Russia
[6
]Research and Development, Bristol-Myers Squibb, Inc., Wallingford, Connecticut, United
States of America
Taipei Veterans General Hospital, TAIWAN
Author notes
Competing Interests: Grants were provided by Bristol-Myers Squib, Achillion, AbbVie, Gilead, Beckman-Colter,
Beohringer-Ingelheim, Conatus, CymaBay, Galectin, Immuron, Intercept, Lumena, NGMBio.
The authors of this manuscript are also employed by Bristol-Myers Squib (S. S., K.
R., Y. D.).
-
Conceived and designed the experiments: SS YD.
-
Performed the experiments: RF MS JA HC IN.
-
Analyzed the data: RF MS JA HC IN KR SS.
-
Contributed reagents/materials/analysis tools: YD KR SS.
-
Wrote the paper: RF MS JA HC IN YD KR SS.
Article
Publisher ID:
PONE-D-16-12779
DOI: 10.1371/journal.pone.0164563
PMC ID: 5066958
PubMed ID: 27749900
SO-VID: 7f8a3530-f6fb-40b3-8ff7-9f577ec7bb59
Copyright © © 2016 Flisiak et al
License:
This is an open access article distributed under the terms of the
Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided
the original author and source are credited.
Funded by: funder-id http://dx.doi.org/10.13039/100002491, Bristol-Myers Squibb;
Bristol-Myers Squibb (the sponsor) designed the study in collaboration with the academic
investigators (Robert Flisiak, Mitchell Shiffman, Juan Arenas, Hugo Cheinquer, and
Igor Nikitin), conducted the study, collected study data, and performed statistical
analyses. The sponsor, together with all authors, interpreted the data and drafted
the manuscript with the assistance of a medical writer funded by the sponsor. Authors
employed by the sponsor (Yuping Dong, Khurram Rana, and Subasree Srinivasan), in concert
with all other authors, approved the final manuscript and made the decision to submit
the manuscript for publication.
Subject:
Research Article
Subject:
Biology and life sciences
Subject:
Organisms
Subject:
Viruses
Subject:
RNA viruses
Subject:
Flaviviruses
Subject:
Hepacivirus
Subject:
Hepatitis C virus
Subject:
Biology and life sciences
Subject:
Microbiology
Subject:
Medical microbiology
Subject:
Microbial pathogens
Subject:
Viral pathogens
Subject:
Flaviviruses
Subject:
Hepacivirus
Subject:
Hepatitis C virus
Subject:
Medicine and health sciences
Subject:
Pathology and laboratory medicine
Subject:
Pathogens
Subject:
Microbial pathogens
Subject:
Viral pathogens
Subject:
Flaviviruses
Subject:
Hepacivirus
Subject:
Hepatitis C virus
Subject:
Biology and life sciences
Subject:
Organisms
Subject:
Viruses
Subject:
Viral pathogens
Subject:
Flaviviruses
Subject:
Hepacivirus
Subject:
Hepatitis C virus
Subject:
Biology and life sciences
Subject:
Microbiology
Subject:
Medical microbiology
Subject:
Microbial pathogens
Subject:
Viral pathogens
Subject:
Hepatitis viruses
Subject:
Hepatitis C virus
Subject:
Medicine and health sciences
Subject:
Pathology and laboratory medicine
Subject:
Pathogens
Subject:
Microbial pathogens
Subject:
Viral pathogens
Subject:
Hepatitis viruses
Subject:
Hepatitis C virus
Subject:
Biology and life sciences
Subject:
Organisms
Subject:
Viruses
Subject:
Viral pathogens
Subject:
Hepatitis viruses
Subject:
Hepatitis C virus
Subject:
Biology and Life Sciences
Subject:
Biochemistry
Subject:
Proteins
Subject:
Interferons
Subject:
Medicine and Health Sciences
Subject:
Gastroenterology and Hepatology
Subject:
Liver Diseases
Subject:
Cirrhosis
Subject:
Biology and Life Sciences
Subject:
Biochemistry
Subject:
Enzymology
Subject:
Enzymes
Subject:
Transferases
Subject:
Aminotransferases
Subject:
Biology and Life Sciences
Subject:
Biochemistry
Subject:
Proteins
Subject:
Enzymes
Subject:
Transferases
Subject:
Aminotransferases
Subject:
Research and Analysis Methods
Subject:
Research Design
Subject:
Clinical Research Design
Subject:
Adverse Events
Subject:
Medicine and Health Sciences
Subject:
Gastroenterology and Hepatology
Subject:
Liver Diseases
Subject:
Chronic Liver Disease
Subject:
Chronic Hepatitis
Subject:
Biology and Life Sciences
Subject:
Toxicology
Subject:
Toxicity
Subject:
Medicine and Health Sciences
Subject:
Pathology and Laboratory Medicine
Subject:
Toxicology
Subject:
Toxicity
Subject:
Biology and Life Sciences
Subject:
Veterinary Science
Subject:
Veterinary Diseases