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      Egg yolk IgY antibodies: A therapeutic intervention against group A rotavirus in calves

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          Abstract

          Bovine group A rotavirus (RVA) is considered the major cause of diarrhea in intensively reared neonatal calves. Chicken egg yolk antibodies (IgY) are efficient in protecting neonatal calves from RVA diarrhea; however, the value of this intervention in calves once diarrhea has appeared is unclear. The aim of the present study was to evaluate the application of RVA-specific IgY as a passive treatment in those cases. The experimental groups were: G1 = RVA-specific IgY treatment; G2 = no Ab treatment; and G3 = colostrum deprived + no Ab treatment. IgY treatment significantly reduced virus shedding, diarrhea duration and severity compared to G2 and G3 calves. However, it caused a partial suppression of systemic Ab responses to RVA that could be associated with less severe diarrhea. The oral treatment with IgY for 7 days was associated with significantly higher antibody secreting cell responses in the calves compared with other groups of animals.

          Highlights

          • •

            Neonatal calf diarrhea is a critical problem and passive therapy with IgY Abs is a way to control it.

          • •

            There are no solid studies using rotavirus specific IgY Abs once calves suffer from diarrhea.

          • •

            We provide here scientific information regarding the effects of IgY-based products.

          • •

            This information is critical considering that IgY Abs are being sold in several countries.

          • •

            We prove the therapeutic value of IgY-based treatment and the industrialization of this product.

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          Most cited references41

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          Zoonotic aspects of rotaviruses.

          V Martella, Krisztián Bányai, Jelle Matthijnssens … (2010)
          Rotaviruses are important enteric pathogens of humans and animals. Group A rotaviruses (GARVs) account for up to 1 million children deaths each year, chiefly in developing countries and human vaccines are now available in many countries. Rotavirus-associated enteritis is a major problem in livestock animals, notably in young calves and piglets. Early in the epidemiological GARV studies in humans, either sporadic cases or epidemics by atypical, animal-like GARV strains were described. Complete genome sequencing of human and animal GARV strains has revealed a striking genetic heterogeneity in the 11 double stranded RNA segments across different rotavirus strains and has provided evidence for frequent intersections between the evolution of human and animal rotaviruses, as a result of multiple, repeated events of interspecies transmission and subsequent adaptation. Copyright 2009 Elsevier B.V. All rights reserved.
          Article 0 comments Cited 142 times – based on 0 reviews     Review now
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            Chicken egg yolk antibodies (IgY-technology): a review of progress in production and use in research and human and veterinary medicine.

            Rüdiger Schade, Esteban Calzado, Rodolfo Sarmiento González … (2005)
            The production of antibodies (Abs) in chickens and the extraction of specific Abs from egg yolk (IgY Abs) are increasingly attracting the interest of the scientific community, as demonstrated by the significant growth of the IgY literature. This review offers detailed and comprehensive information about IgY-technology, including: a) possibilities for hen keeping in accordance with the Three Rs principles; b) new insights into the IgY transfer mechanism from blood to yolk as a biological basis for the technology; c) the comparative characteristics of IgY Abs and IgG Abs; d) the high efficacy of the technique, in view of the extraordinary amount of IgY Ab produced by one hen in one year (between 20 g and 40 g IgY in total); e) comparisons between the efficacies of IgY Abs and IgG Abs (rabbit, sheep, mouse) in several immunological assays; f) immunisation protocols, as well as the most commonly used IgY-extraction procedures; g) new possibilities for application in human and veterinary medicine, including strategies for the treatment of Helicobacter pylori infection or fatal intestinal diseases in children, particularly in poor countries, for reducing the use of antibiotics, and, in Asia and South America, for producing Abs against snake, spider and scorpion venoms; and h) the use of IgY Abs in various fields of research, also taking into consideration recent developments in South America (particularly Argentina and Cuba) and in Asia.
            Article 0 comments Cited 85 times – based on 0 reviews     Review now
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              Egg yolk antibodies for passive immunity.

              Yoshinori MINE, John Nolan (2011)
              The avian egg contains all of the necessary nutrients and growth factors required for the developing embryo, including antibodies that are transported from the blood of the hen into the egg yolk to provide immunity to the chick. Since the discovery of egg yolk antibodies, now called immunoglobulin Y (IgY), in the late 1800s, this process has been harnessed to produce antigen-specific yolk antibodies for numerous applications in the medical and research fields, including in areas such as diagnostics and proteomics. However, one of the most valuable and promising areas of IgY research is its use for passive immunization to treat and prevent human and animal diseases. The following review covers the key features and advantages of IgY and the production and purification of IgY from the egg yolk, as well as highlights some of the most promising applications of egg yolk antibodies in human and veterinary medicine.
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                Author and article information

                Contributors
                V. Parreño
                Journal
                Journal ID (nlm-ta): Res Vet Sci
                Journal ID (iso-abbrev): Res. Vet. Sci
                Title: Research in Veterinary Science
                Publisher: Elsevier Ltd. Published by Elsevier Ltd.
                ISSN (Print): 0034-5288
                ISSN (Electronic): 1532-2661
                Publication date PMC-release: 8 September 2015
                Publication date (Print): December 2015
                Publication date (Electronic): 8 September 2015
                Volume: 103
                Pages: 1-10
                Affiliations
                [a ]Instituto de Virología, CICV y A - INTA, Castelar, Buenos Aires CC 25 (1712), Argentina
                [b ]Food Animal Health Research Program (FAHRP), The Ohio Agricultural Research and Development Center, The Ohio State University, Columbus, USA
                Author notes
                [* ]Corresponding author. parreno.viviana@ 123456inta.gob.ar
                Article
                Publisher ID: S0034-5288(15)30053-9
                DOI: 10.1016/j.rvsc.2015.09.005
                PMC ID: 4684595
                PubMed ID: 26679788
                SO-VID: 7fd5c0d5-c7a8-487b-b981-17664bcf9c45
                Copyright © Copyright © 2015 Elsevier Ltd. Published by Elsevier Ltd. All rights reserved.
                License:

                Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.

                History
                Date received : 5 May 2015
                Date revision received : 1 September 2015
                Date accepted : 4 September 2015
                Categories
                Subject: Article

                ScienceOpen disciplines: Veterinary medicine
                Keywords: bovine,rotavirus,passive immunity,chicken antibodies,igy
                Data availability:
                ScienceOpen disciplines: Veterinary medicine
                Keywords: bovine, rotavirus, passive immunity, chicken antibodies, igy

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