6
views
0
recommends
+1 Recommend
0 collections
    0
    shares
      • Record: found
      • Abstract: found
      • Article: not found

      Stressing the role of FoxO proteins in lifespan and disease.

      Nature reviews. Molecular cell biology

      Aging, physiology, Animals, Disease, Forkhead Transcription Factors, classification, genetics, metabolism, Glucose, Humans, Life Expectancy, Models, Biological, Protein Isoforms, Protein Processing, Post-Translational, Tumor Suppressor Protein p53

      Read this article at

      ScienceOpenPublisherPubMed
      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          Members of the class O of forkhead box transcription factors (FoxO) have important roles in metabolism, cellular proliferation, stress tolerance and probably lifespan. The activity of FoxOs is tightly regulated by post-translational modifications, including phosphorylation, acetylation and ubiquitylation. Several of the enzymes that regulate the turnover of these post-translational modifications are shared between FoxO and p53. These regulatory enzymes affect FoxO and p53 function in an opposite manner. This shared yet opposing regulatory network between FoxOs and p53 may underlie a 'trade-off' between disease and lifespan.

          Related collections

          Author and article information

          Journal
          17522590
          10.1038/nrm2190

          Comments

          Comment on this article