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Abstract
Inhibition of the α-glucosidase activity is a therapeutic approach for diabetes. In
this study, an effective strategy for screening α-glucosidase inhibitors based on
Nuclear magnetic resonance (NMR) techniques was developed to screen and identify α-glucosidase
inhibitors from Mulberry leaf extract. As a result, deoxynojirimycin, as a potential
α-glucosidase inhibitor, was found. The study suggested that our strategy was a powerful
tool for screening and identification of α-glucosidase inhibitors in complex samples.
Furthermore the interaction between α-glucosidase and its inhibitor was studied by
NMR.