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      Morphological and Biochemical Changes in Lenses of Guinea Pigs after Vitamin-C-Deficient Diet and UV-B Radiation

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          Abstract

          The effect of ultraviolet B (UV-B) radiation and a vitamin C-deficient (VCD) diet on guinea pig lenses was investigated. The initial lens changes in the VCD group were observed by slit-lamp examination 6 weeks after the start of the VCD treatment; after 12 weeks the changes in the posterior subcapsular region became more prominent, and the dissociation around the posterior suture became wider and slightly deeper toward the posterior cortex. The high concentration of lens oxidized glutathione (GSSG), and the low ratio of reduced glutathione (GSH) to oxidized glutathione (GSH/GSSG) on the lens posterior region correlated with density changes in the corresponding layers as measured by Scheimpflug images with linear microdensitometry. It is suggested that the strong oxidative stress of the VCD diet caused the damage at the posterior part of the lens. UV-B radiation appeared to accelerate cataract progression in lenses that lack vitamin C.

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          Author and article information

          Journal
          ORE
          Ophthalmic Res
          10.1159/issn.0030-3747
          Ophthalmic Research
          S. Karger AG
          0030-3747
          1423-0259
          1995
          1995
          11 December 2009
          : 27
          : 4
          : 189-196
          Affiliations
          aDepartment of Biochemistry, Faculty of Medicine, University of Andalas, Padang, Indonesia, and bDepartment of Ophthalmology, Kanazawa Medical University, Ishikawa, Japan
          Article
          267704 Ophthalmic Res 1995;27:189–196
          10.1159/000267704
          8538997
          © 1995 S. Karger AG, Basel

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          Page count
          Pages: 8
          Categories
          Original Paper

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