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A randomised trial of primary tamoxifen versus mastectomy plus adjuvant tamoxifen in fit elderly women with invasive breast carcinoma of high oestrogen receptor content: long-term results at 20 years of follow-up
S.J. Johnston ,
F.S. Kenny ,
B.M. Syed ,
J.F.R. Robertson ,
S.E. Pinder ,
L. Winterbottom ,
I.O. Ellis ,
R.W. Blamey ,
K.L. Cheung
September 2012
September 2012
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Abstract
Long-term analysis of a randomised trial in Nottingham comparing tamoxifen versus
surgery as initial treatment demonstrated that in oestrogen receptor (ER)-unselected
cases, surgery achieved better local control, with no difference in overall survival.
It was suggested that for patients with ER-rich tumours, local control and survival
may be comparable. We now present long-term follow-up of a randomised trial designed
to address this clinical scenario.