The soluble guanylyl cyclase activator BAY 60-2770 potently relaxes the pulmonary artery on congenital diaphragmatic hernia rabbit model.

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Abstract

Congenital diaphragmatic hernia (CDH) is associated with pulmonary hypertension which is often difficult to manage, and a significant cause of morbidity and mortality. In this study, we have used a rabbit model of CDH to evaluate the effects of BAY 60-2770 on the in vitro reactivity of left pulmonary artery.

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Journal

Journal ID (iso-abbrev): Pediatr Surg Int

Title: Pediatric surgery international

Publisher: Springer Science and Business Media LLC

ISSN (Electronic): 1437-9813

ISSN (Print): 0179-0358

Publication date (Electronic): Oct 2014

Volume: 30

Issue: 10

Affiliations

[1 ] Department of Pharmacology, Faculty of Medical Sciences, University of Campinas-UNICAMP, Campinas, SP, Brazil.

Article

DOI: 10.1007/s00383-014-3561-3

PubMed ID: 25062768

SO-VID: 8250eba9-e71e-4c84-866f-74754293777b

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