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Coordinated Neuronal Activity Enhances Corticocortical Communication.

1 , 2

Neuron

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      Abstract

      Relaying neural signals between cortical areas is central to cognition and sensory processing. The temporal coordination of activity in a source population has been suggested to determine corticocortical signaling efficacy, but others have argued that coordination is functionally irrelevant. We reasoned that if coordination significantly influenced signaling, spiking in downstream networks should be preceded by transiently elevated coordination in a source population. We developed a metric to quantify network coordination in brief epochs, and applied it to simultaneous recordings of neuronal populations in cortical areas V1 and V2 of the macaque monkey. Spiking in the input layers of V2 was preceded by brief epochs of elevated V1 coordination, but this was not the case in other layers of V2. Our results indicate that V1 coordination influences its signaling to direct downstream targets, but that coordinated V1 epochs do not propagate through multiple downstream networks as in some corticocortical signaling schemes.

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      Affiliations
      [1 ] Dominick Purpura Department of Neuroscience, Albert Einstein College of Medicine, Bronx, NY 10461, USA. Electronic address: zandvakili@gmail.com.
      [2 ] Dominick Purpura Department of Neuroscience, Albert Einstein College of Medicine, Bronx, NY 10461, USA; Department of Ophthalmology and Visual Sciences, Albert Einstein College of Medicine, Bronx, NY 10461, USA; Department of Systems and Computational Biology, Albert Einstein College of Medicine, Bronx, NY 10461, USA. Electronic address: adam.kohn@einstein.yu.edu.
      Journal
      Neuron
      Neuron
      1097-4199
      0896-6273
      Aug 19 2015
      : 87
      : 4
      S0896-6273(15)00648-0 10.1016/j.neuron.2015.07.026 26291164 4545497 NIHMS712559
      Copyright © 2015 Elsevier Inc. All rights reserved.

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