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      Changes in Glomerular Basement Membrane Collagen Caused by DOCA-NaCl Treatment in Rats

      , ,

      Nephron

      S. Karger AG

      Glomerular basement membrane, Unilateral nephrectomy, Collagen synthesis

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          Abstract

          The influence of hypertensive regime on collagen synthesis in glomerular basement membranes of rats was studied. Isolated glomeruli were incubated in a medium containing <sup>14</sup>C-labeled proline. It was demonstrated that there was a higher proline incorporation and proline conversion to hydroxyproline in rats kept on the hypertensive regime. However, solubilization of the collagenous fraction by limited pepsin digestion did not reveal any qualitative changes in the collagen type deposited. It is concluded that the DOCA-NaCl treatment in rats results in an intensive accumulation of collagen, mainly of type IV, typical for basement membranes.

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          Author and article information

          Journal
          NEF
          Nephron
          10.1159/issn.1660-8151
          Nephron
          S. Karger AG
          1660-8151
          2235-3186
          1985
          1985
          04 December 2008
          : 39
          : 3
          : 250-254
          Affiliations
          Institute of Physiology, Czechoslovak Academy of Sciences, Prague, Czechoslovakia
          Article
          183380 Nephron 1985;39:250–254
          10.1159/000183380
          3974784
          © 1985 S. Karger AG, Basel

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          Page count
          Pages: 5
          Categories
          Original Paper

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