Changes in Glomerular Basement Membrane Collagen Caused by DOCA-NaCl Treatment in Rats

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Abstract

The influence of hypertensive regime on collagen synthesis in glomerular basement membranes of rats was studied. Isolated glomeruli were incubated in a medium containing <sup>14</sup>C-labeled proline. It was demonstrated that there was a higher proline incorporation and proline conversion to hydroxyproline in rats kept on the hypertensive regime. However, solubilization of the collagenous fraction by limited pepsin digestion did not reveal any qualitative changes in the collagen type deposited. It is concluded that the DOCA-NaCl treatment in rats results in an intensive accumulation of collagen, mainly of type IV, typical for basement membranes.

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Author and article information

Journal

Journal ID (publisher-id): NEF

Journal ID (nlm-ta): Nephron

Journal ID (doi): 10.1159/issn.1660-8151

Title: Nephron

Publisher: S. Karger AG

ISSN (Print): 1660-8151

ISSN (Electronic): 2235-3186

Publication date Subscription-year: 1985

Publication date (Print): 1985

Publication date (Electronic): 04 December 2008

Volume: 39

Issue: 3

Pages: 250-254

Affiliations

Institute of Physiology, Czechoslovak Academy of Sciences, Prague, Czechoslovakia

Article

Publisher ID: 183380 Other ID: Nephron 1985;39:250–254

DOI: 10.1159/000183380

PubMed ID: 3974784

SO-VID: 8281e755-d7e5-4263-9596-601c80923964

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Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

History

Date accepted : 26 January 1984

Page count

Pages: 5

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