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Tau phosphorylation sites serine202 and serine396 are differently altered in chronic traumatic encephalopathy and Alzheimer's disease
SpiroAnthony Stathas
1
,
2 ,
Victor E. Alvarez
1
,
2
,
3
,
4 ,
Weiming Xia
1
,
2 ,
Raymond Nicks
1
,
2 ,
Gaoyuan Meng
1
,
2
,
4 ,
Sarah Daley
1
,
2 ,
Morgan Pothast
1 ,
Arsal Shah
1
,
4 ,
Hunter Kelley
1 ,
Camille Esnault
1 ,
Robert McCormack
1 ,
Erin Dixon
1 ,
Lucas Fishbein
1 ,
Jonathan D. Cherry
1
,
3
,
4 ,
Bertrand R. Huber
1
,
3
,
4 ,
Yorghos Tripodis
1
,
5 ,
Michael L. Alosco
1
,
3 ,
Jesse Mez
1
,
3 ,
Ann C. McKee
1
,
2
,
3
,
4
,
6 ,
Thor D. Stein
1
,
2
,
3
,
4
,
6
December 02 2021
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Abstract
Chronic traumatic encephalopathy (CTE) is a neurodegenerative tauopathy associated
with repetitive head impacts (RHI) typically sustained by contact sport athletes.
Post-translation modifications to tau in CTE have not been well delineated or compared
to Alzheimer's disease (AD).