Vincenzo Malagnino: Role: ConceptualizationRole: Data curation
Romina Salpini: Role: ConceptualizationRole: Formal analysis
Gaetano Maffongelli: Role: Data curationRole: Methodology
Arianna Battisti: Role: Data curationRole: Formal analysis
Lavinia Fabeni: Role: Data curationRole: Methodology
Lorenzo Piermatteo: Role: Data curationRole: Formal analysis
Luna Colagrossi: Role: Data curationRole: Formal analysis
Vanessa Fini: Role: Data curationRole: Formal analysis
Alessandra Ricciardi: Role: Data curationRole: Methodology
Cesare Sarrecchia: Role: Data curationRole: Methodology
Carlo Federico Perno: Role: ConceptualizationRole: SupervisionRole: Writing – review & editing
Massimo Andreoni: Role: ConceptualizationRole: VisualizationRole: Writing – review & editing
Valentina Svicher: Role: ConceptualizationRole: Data curationRole: SupervisionRole: Writing – original
draftRole: Writing – review & editing
Loredana Sarmati:
ORCID: http://orcid.org/0000-0003-1452-0333
Role: ConceptualizationRole: Formal analysisRole: SupervisionRole: Writing – original
draftRole: Writing – review & editing
Ferruccio Bonino: Role: Editor
Journal ID (nlm-ta): PLoS One
Journal ID (iso-abbrev): PLoS ONE
Journal ID (publisher-id): plos
Journal ID (pmc): plosone
Title:
PLoS ONE
Publisher:
Public Library of Science
(San Francisco, CA USA
)
ISSN
(Electronic):
1932-6203
Publication date
(Electronic):
29
March
2018
Publication date Collection: 2018
Volume: 13
Issue: 3
Electronic Location Identifier: e0195045
Affiliations
[1
]
Clinical Infectious Diseases, Department of System Medicine, Tor Vergata University,
Rome, Italy
[2
]
Department of Experimental Medicine and Surgery, Tor Vergata University, Rome, Italy
Universita degli Studi di Pisa, ITALY
Author notes
Competing Interests: MA and CFP received speaker fees, travel grants, and consulting fees from Abbvie,
Bristol-Myers Squibb, Gilead Sciences, Merck Sharp & Dohme, ViiV Healthcare, and Janssen-Cilag.
LS received travel grants from Gilead Sciences and Merck Sharp & Dohme; payment for
lectures from Gilead Sciences, Merck Sharp & Dohme and Abbvie; and researcher funding
from Gilead. VS received grants from Bristol-Myers Squibb, Gilead Sciences, and Roche.
This does not altered our adherence to PLO ONE policies on sharing data and materials.
‡ These authors are joint last authors on this work.
Author information
Article
Publisher ID:
PONE-D-17-36120
DOI: 10.1371/journal.pone.0195045
PMC ID: 5875859
PubMed ID: 29596494
SO-VID: 83143a7b-62dd-4aba-bef0-4e65fe148a5d
Copyright © © 2018 Malagnino et al
License:
This is an open access article distributed under the terms of the
Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided
the original author and source are credited.
Funded by: FIRB project (RBAP11YS7K_001),
Award Recipient
:
Valentina Svicher
Funded by: University and Research (Progetto Bandiera PB05)
Award Recipient
:
Carlo Federico Perno
Funded by: Aviralia Foundation
Award Recipient
:
Carlo Federico Perno
This work was supported by the FIRB project (RBAP11YS7K_001) to VS, by the Italian
Ministry of Instruction, University and Research (Progetto Bandiera PB05), and the
Aviralia Foundation for data collection and analysis to CFP.
Subject:
Research Article
Subject:
Biology and life sciences
Subject:
Microbiology
Subject:
Medical microbiology
Subject:
Microbial pathogens
Subject:
Viral pathogens
Subject:
Hepatitis viruses
Subject:
Hepatitis B virus
Subject:
Medicine and health sciences
Subject:
Pathology and laboratory medicine
Subject:
Pathogens
Subject:
Microbial pathogens
Subject:
Viral pathogens
Subject:
Hepatitis viruses
Subject:
Hepatitis B virus
Subject:
Biology and life sciences
Subject:
Organisms
Subject:
Viruses
Subject:
Viral pathogens
Subject:
Hepatitis viruses
Subject:
Hepatitis B virus
Subject:
People and Places
Subject:
Geographical Locations
Subject:
Africa
Subject:
Medicine and Health Sciences
Subject:
Surgical and Invasive Medical Procedures
Subject:
Biopsy
Subject:
Research and analysis methods
Subject:
Extraction techniques
Subject:
DNA extraction
Subject:
Medicine and Health Sciences
Subject:
Oncology
Subject:
Cancers and Neoplasms
Subject:
Carcinomas
Subject:
Hepatocellular Carcinoma
Subject:
Medicine and Health Sciences
Subject:
Oncology
Subject:
Cancers and Neoplasms
Subject:
Gastrointestinal Tumors
Subject:
Hepatocellular Carcinoma
Subject:
Medicine and Health Sciences
Subject:
Gastroenterology and Hepatology
Subject:
Liver Diseases
Subject:
Hepatocellular Carcinoma
Subject:
Biology and Life Sciences
Subject:
Evolutionary Biology
Subject:
Evolutionary Systematics
Subject:
Phylogenetics
Subject:
Phylogenetic Analysis
Subject:
Biology and Life Sciences
Subject:
Taxonomy
Subject:
Evolutionary Systematics
Subject:
Phylogenetics
Subject:
Phylogenetic Analysis
Subject:
Computer and Information Sciences
Subject:
Data Management
Subject:
Taxonomy
Subject:
Evolutionary Systematics
Subject:
Phylogenetics
Subject:
Phylogenetic Analysis
Subject:
Research and Analysis Methods
Subject:
Database and Informatics Methods
Subject:
Bioinformatics
Subject:
Sequence Analysis
Subject:
Biology and Life Sciences
Subject:
Molecular Biology
Subject:
Molecular Biology Techniques
Subject:
Artificial Gene Amplification and Extension
Subject:
Polymerase Chain Reaction
Subject:
Research and Analysis Methods
Subject:
Molecular Biology Techniques
Subject:
Artificial Gene Amplification and Extension
Subject:
Polymerase Chain Reaction