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Epigenetics and the origins of paternal effects
Author(s):
James P. Curley
,
Rahia Mashoodh
,
Frances A. Champagne
Publication date
Created:
March 2011
Publication date
(Print):
March 2011
Journal:
Hormones and Behavior
Publisher:
Elsevier BV
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Abstract
Though there are multiple routes through which parents can influence their offspring, recent studies of environmentally induced epigenetic variation have highlighted the role of non-genomic pathways. In addition to the experience-dependent modification of DNA methylation that can be achieved via mother-infant interactions, there has been increasing interest in the epigenetic mechanisms through which paternal influences on offspring development can be achieved. Epidemiological and laboratory studies suggest that paternal nutritional and toxicological exposures as well as paternal age and phenotypic variation can lead to variations in offspring and, in some cases, grand-offspring development. These findings suggest a potential epigenetic germline inheritance of paternal effects. However, it may be important to consider the interplay between maternal and paternal influences as well as the experimental dissociation between experience-dependent and germline transmission when exploring the role of epigenetic variation within the germline as a mediator of these effects. In this review, we will explore these issues, with a particular focus on the potential role of paternally induced maternal investment, highlight the literature illustrating the transgenerational impact of paternal experiences, and discuss the evidence supporting the role of epigenetic mechanisms in maintaining paternal effects both within and across generations. Copyright © 2010 Elsevier Inc. All rights reserved.
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Author and article information
Journal
Title:
Hormones and Behavior
Abbreviated Title:
Hormones and Behavior
Publisher:
Elsevier BV
ISSN (Print):
0018506X
Publication date Created:
March 2011
Publication date (Print):
March 2011
Volume
: 59
Issue
: 3
Pages
: 306-314
Article
DOI:
10.1016/j.yhbeh.2010.06.018
PMC ID:
2975825
PubMed ID:
20620140
SO-VID:
83c40ef5-0b98-4b68-80cd-e84faff270f6
Copyright ©
© 2011
License:
https://www.elsevier.com/tdm/userlicense/1.0/
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