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      Imaging SERT Availability in a Rat Model of L-DOPA-Induced Dyskinesia.

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          Abstract

          The development of L-DOPA-induced dyskinesia (LID) is one of the most severe side effects of chronic L-DOPA treatment in Parkinson's disease patients. [11C]DASB positron emission tomography (PET) provides a prominent tool to visualize and quantify serotonin transporter (SERT) pathology in vivo in patients and in animal models. To evaluate the effect of chronic L-DOPA treatment on SERT availability in an animal model of LID, we performed a longitudinal PET study.

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          Author and article information

          Journal
          Journal ID (iso-abbrev): Mol Imaging Biol
          Title: Molecular imaging and biology
          Publisher: Springer Science and Business Media LLC
          ISSN (Electronic): 1860-2002
          ISSN (Print): 1536-1632
          Publication date (Electronic): June 2020
          Volume: 22
          Issue: 3
          Affiliations
          [1 ] Werner Siemens Imaging Center, Department of Preclinical Imaging and Radiopharmacy, Eberhard-Karls University of Tuebingen, Röntgenweg 13, Tuebingen, Germany.
          [2 ] Werner Siemens Imaging Center, Department of Preclinical Imaging and Radiopharmacy, Eberhard-Karls University of Tuebingen, Röntgenweg 13, Tuebingen, Germany. kristina.herfert@med.uni-tuebingen.de.
          Article
          Publisher Item ID: 10.1007/s11307-019-01418-2
          DOI: 10.1007/s11307-019-01418-2
          PubMed ID: 31392531
          SO-VID: 84b44381-dc48-4d49-a6ed-3addc597b447
          History

          Keywords: L-DOPA-induced dyskinesia,PET imaging,Serotonin transporter,[11C]DASB
          Data availability:
          Keywords: L-DOPA-induced dyskinesia, PET imaging, Serotonin transporter, [11C]DASB

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