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      Ginsenoside Rg3 ameliorates acetaminophen-induced hepatotoxicity by suppressing inflammation and oxidative stress.

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          Abstract

          Improper usage of acetaminophen (APAP) leads to morbidity and also mortality secondary to liver damage. Ginseng could suppress APAP-induced hepatotoxicity and ginsenoside Rg3 is a kind of major component in ginseng against liver damage. Herein, we intended to estimate the beneficial function and molecular mechanism of Rg3 on APAP-caused hepatotoxicity and identified hepatoprotection.

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          Author and article information

          Journal
          J Pharm Pharmacol
          The Journal of pharmacy and pharmacology
          Oxford University Press (OUP)
          2042-7158
          0022-3573
          Mar 06 2021
          : 73
          : 3
          Affiliations
          [1 ] Department of Pharmacy, Xuanwu Hospital of Capital Medical University, National Clinical Research Center for Geriatric Diseases, Beijing Engineering Research Center for Nervous System Drugs, Beijing Institute for Brain Disorders, Key Laboratory for Neurodegenerative Diseases of Ministry of Education, Beijing, China.
          [2 ] State Key Laboratory of Bioactive Substances and Functions of Natural Medicines, Institute of Materia Medica and Neuroscience Center, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
          [3 ] Department of Pharmacy, National Cancer Center/National Clinical Research Center for Cancer, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
          [4 ] Science and Technology Innovation Center, Guangzhou University of Chinese Medicine, Guangzhou, China.
          [5 ] College of Pharmacy, Hunan University of Chinese Medicine, Changsha, China.
          Article
          6124642
          10.1093/jpp/rgaa069
          33793882
          85aa4f26-4ed4-45e9-b8c6-f3138f19abb6
          History

          ginsenoside Rg3,Luminex analysis,acetaminophen,hepatic damage,molecular docking

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