Double-Blind Evaluation of Practolol and Quinidine in the Treatment of Chronic Atrial Fibrillation

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Abstract

54 patients with chronic atrial fibrillation were randomly divided into two groups and treated respectively with practolol and quinidine (26 cases) and with placebo and quinidine (28 cases). Sinus rhythm was restored in about the same percentage of cases in the two groups (42.3 and 46.4%). This suggests the following conclusions: practolol is devoid of therapeutic activity in the treatment of chronic atrial fibrillation; in agreement with similar observations made with other β-adrenergic blocking agents (propranolol, LB 46, and alprenolol), practolol seems to protect the myocardium from the onset of severe ventricular arrhythmia during the course of quinidine therapy.

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Journal ID (publisher-id): CRD

Journal ID (nlm-ta): Cardiology

Journal ID (doi): 10.1159/issn.0008-6312

Title: Cardiology

Publisher: S. Karger AG

ISSN (Print): 0008-6312

ISSN (Electronic): 1421-9751

Publication date Subscription-year: 1973

Publication date (Print): 1973

Publication date (Electronic): 29 October 2008

Volume: 58

Issue: 6

Pages: 364-368

Affiliations

Brescia Civil Hospitals, 4th Division of General Medicine, Brescia

Article

Publisher ID: 169654 Other ID: Cardiology 1973;58:364–368

DOI: 10.1159/000169654

PubMed ID: 4608474

SO-VID: 85b8b2f6-8da9-439d-bc15-bc5ebe7f093d

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Double-Blind Evaluation of Practolol and Quinidine in the Treatment of Chronic Atrial Fibrillation

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Karger: Cardiovascular System

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