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      Double-Blind Evaluation of Practolol and Quinidine in the Treatment of Chronic Atrial Fibrillation

      , ,

      Cardiology

      S. Karger AG

      Practolol, <italic>β</italic>-Blockers, Atrial fibrillation, Quinidine

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          Abstract

          54 patients with chronic atrial fibrillation were randomly divided into two groups and treated respectively with practolol and quinidine (26 cases) and with placebo and quinidine (28 cases). Sinus rhythm was restored in about the same percentage of cases in the two groups (42.3 and 46.4%). This suggests the following conclusions: practolol is devoid of therapeutic activity in the treatment of chronic atrial fibrillation; in agreement with similar observations made with other β-adrenergic blocking agents (propranolol, LB 46, and alprenolol), practolol seems to protect the myocardium from the onset of severe ventricular arrhythmia during the course of quinidine therapy.

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          Author and article information

          Journal
          CRD
          Cardiology
          10.1159/issn.0008-6312
          Cardiology
          S. Karger AG
          0008-6312
          1421-9751
          1973
          1973
          29 October 2008
          : 58
          : 6
          : 364-368
          Affiliations
          Brescia Civil Hospitals, 4th Division of General Medicine, Brescia
          Article
          169654 Cardiology 1973;58:364–368
          10.1159/000169654
          4608474
          © 1973 S. Karger AG, Basel

          Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

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          Pages: 5
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