The Expression of Water Channels AQP1 and AQP2 in a Large Series of ADPKD Kidneys

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Abstract

We read with interest the paper by Hayashi et al. [1] reporting the expression of AQP2 and AQP3 in cyst-lining epithelial cells from ADPKD kidneys. The authors suggest that about 30% of the cysts in ADPKD are derived from collecting-duct cells and that these cells remain well differentiated in terms of AQP expression. However, these conclusions are limited by the small number of ADPKD kidneys (n = 2) studied and by the fact that both AQP2 and AQP3 are located in the same cells – the principal cells of the collecting duct.

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Journal ID (publisher-id): NEF

Journal ID (nlm-ta): Nephron

Journal ID (doi): 10.1159/issn.1660-8151

Title: Nephron

Publisher: S. Karger AG

ISSN (Print): 1660-8151

ISSN (Electronic): 2235-3186

Publication date Subscription-year: 1998

Publication date (Print): January 1998

Publication date (Electronic): 19 December 1997

Volume: 78

Issue: 1

Page: 116

Affiliations

Division of Nephrology, St. Luc Academic Hospital, University of Louvain Medical School, Brussels, Belgium

Article

Publisher ID: 44893 Other ID: Nephron 1998;78:116

DOI: 10.1159/000044893

PubMed ID: 9453414

SO-VID: 87883bdf-6239-496b-b1f7-4b47929fa744

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The Expression of Water Channels AQP1 and AQP2 in a Large Series of ADPKD Kidneys

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Karger: Nephrology

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