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      Call for Papers: Sex and Gender in Neurodegenerative Diseases

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      About Neurodegenerative Diseases: 3.0 Impact Factor I 4.3 CiteScore I 0.695 Scimago Journal & Country Rank (SJR)

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      Incremental Validity of Montreal Cognitive Assessment Index Scores in Mild Cognitive Impairment and Alzheimer Disease

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          Abstract

          Background/Aims: The aim of this paper was to evaluate the incremental validity of the Montreal Cognitive Assessment (MoCA) index scores and the MoCA total score in differentiating individuals with normal cognition versus mild cognitive impairment (MCI) or Alzheimer disease (AD). Methods: Effect sizes were calculated for Alzheimer’s Disease Neuroimaging Initiative research participants with normal cognition ( n = 295), MCI ( n = 471), or AD ( n = 150). Results: Effect sizes for the total score were large (> 0.80) and exceeded the index scores in differentiating those with MCI versus normal cognition, MCI versus AD, and AD versus normal cognition. A combined score incorporating the Memory, Executive, and Orientation indexes also improved incremental validity for all 3 group comparisons. Conclusion: Administration of the entire MoCA is more informative than the index scores, especially in distinguishing normal cognition versus MCI. A combined score has stronger incremental validity than the individual index scores.

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          Montreal Cognitive Assessment Memory Index Score (MoCA-MIS) as a predictor of conversion from mild cognitive impairment to Alzheimer's disease.

          Parunyou Julayanont, Mélanie Brousseau, Howard Chertkow … (2014)
          To assess the usefulness of the Montreal Cognitive Assessment (MoCA) total score (MoCA-TS) and Memory Index Score (MoCA-MIS) in predicting conversion to Alzheimer's disease (AD) in individuals with mild cognitive impairment (MCI).
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            Effect Size (Cohen's d) of Cognitive Screening Instruments Examined in Pragmatic Diagnostic Accuracy Studies

            Andrew J. Larner (2014)
            Background/Aims: Many cognitive screening instruments (CSI) are available to clinicians to assess cognitive function. The optimal method comparing the diagnostic utility of such tests is uncertain. The effect size (Cohen's d), calculated as the difference of the means of two groups divided by the weighted pooled standard deviations of these groups, may permit such comparisons. Methods: Datasets from five pragmatic diagnostic accuracy studies, which examined the Mini-Mental State Examination (MMSE), the Mini-Mental Parkinson (MMP), the Six-Item Cognitive Impairment Test (6CIT), the Montreal Cognitive Assessment (MoCA), the Test Your Memory test (TYM), and the Addenbrooke's Cognitive Examination-Revised (ACE-R), were analysed to calculate the effect size (Cohen's d) for the diagnosis of dementia versus no dementia and for the diagnosis of mild cognitive impairment versus no dementia (subjective memory impairment). Results: The effect sizes for dementia versus no dementia diagnosis were large for all six CSI examined (range 1.59-1.87). For the diagnosis of mild cognitive impairment versus no dementia, the effect sizes ranged from medium to large (range 0.48-1.45), with MoCA having the largest effect size. Conclusion: The calculation of the effect size (Cohen's d) in diagnostic accuracy studies is straightforward. The routine incorporation of effect size calculations into diagnostic accuracy studies merits consideration in order to facilitate the comparison of the relative value of CSI.
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              Cognitive screening instruments for the diagnosis of mild cognitive impairment : MCI diagnosis

              Andrew J Larner (2016)
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                Author and article information

                Journal
                Journal ID (publisher-id): DEM
                Journal ID (nlm-ta): Dement Geriatr Cogn Disord
                Journal ID (doi): 10.1159/issn.1420-8008
                Title: Dementia and Geriatric Cognitive Disorders
                Publisher: S. Karger AG
                ISSN (Print): 1420-8008
                ISSN (Electronic): 1421-9824
                Publication date Subscription-year: 2018
                Publication date (Print): May 2018
                Publication date (Electronic): 11 April 2018
                Volume: 45
                Issue: 1-2
                Pages: 49-55
                Affiliations
                Neuropsychology Program, Department of Neurology, Emory University School of Medicine, Atlanta, Georgia, USA
                Author notes
                *Felicia C. Goldstein, PhD, Brain Health Center, 12 Executive Park, NE, Atlanta, GA 30329 (USA), E-Mail fgoldst@emory.edu
                Article
                Publisher ID: 487131 Pmcid ID: PMC5971132 Other ID: Dement Geriatr Cogn Disord 2018;45:49–55
                DOI: 10.1159/000487131
                PMC ID: PMC5971132
                PubMed ID: 29642074
                SO-VID: 87a3dbaf-308d-4ecc-831b-19220ccb967e
                Copyright © © 2018 S. Karger AG, Basel
                License:

                Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

                History
                Date received : 24 November 2017
                Date accepted : 23 January 2018
                Page count
                Tables: 3, Pages: 7
                Categories
                Subject: Original Research Article

                ScienceOpen disciplines: Geriatric medicine,Neurology,Cardiovascular Medicine,Neurosciences,Clinical Psychology & Psychiatry,Public health
                Keywords: Montreal Cognitive Assessment,Montreal Cognitive Assessment index scores,Incremental validity,Mild cognitive impairment,Alzheimer disease
                Data availability:
                ScienceOpen disciplines: Geriatric medicine, Neurology, Cardiovascular Medicine, Neurosciences, Clinical Psychology & Psychiatry, Public health
                Keywords: Montreal Cognitive Assessment, Montreal Cognitive Assessment index scores, Incremental validity, Mild cognitive impairment, Alzheimer disease

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