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      Reduction by granulocyte colony-stimulating factor of fever and neutropenia induced by chemotherapy in patients with small-cell lung cancer.

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          Abstract

          Neutropenia and infection are major dose-limiting side effects of chemotherapy. Previous studies have suggested that recombinant methionyl granulocyte colony-stimulating factor (G-CSF) can reduce chemotherapy-related neutropenia in patients with cancer. We conducted a randomized clinical trial to test this hypothesis and the clinical implications.

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          Author and article information

          Journal
          N Engl J Med
          The New England journal of medicine
          Massachusetts Medical Society
          0028-4793
          0028-4793
          Jul 18 1991
          : 325
          : 3
          Affiliations
          [1 ] Duke University Medical Center, Durham, N.C. 27710.
          Article
          10.1056/NEJM199107183250305
          1711156
          893f67d4-5dd5-4b50-b0e5-431dc18e879b
          History

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