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      Overview of Dementia Lacking Distinctive Histology: Pathological Designation of a Progressive Dementia

      Dementia and Geriatric Cognitive Disorders

      S. Karger AG

      Dementia, Frontal lobes

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          Abstract

          The group of progressive dementing illnesses that lack distinctive histologic features includes at least four variants: a cortical type, a thalamostriate type, a motor neuronopathy type and a Ieukogliotic type. While the clinical presentation of some cases is that of anterograde amnesia, progressive aphasia and dysexecutive syndrome are the most common initial symptom complexes. A large number of reported cases are familial, although no abnormal gene has been identified. Pathologically, these illnesses are defined by cortical, hippocampal, striatal, medial thalamic, nigral and motor nuclei cell dropout and astrogliosis. In some cases, white matter gliosis is striking. Identification of specific histological or molecular markers of at least some of these conditions will greatly advance our understanding of these specific conditions as well as dementing illnesses in general.

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          Author and article information

          Journal
          DEM
          Dement Geriatr Cogn Disord
          10.1159/issn.1420-8008
          Dementia and Geriatric Cognitive Disorders
          S. Karger AG
          978-3-8055-5824-2
          978-3-8055-8760-0
          1420-8008
          1421-9824
          1993
          1993
          27 July 1993
          : 4
          : 3-4
          : 132-136
          Affiliations
          Department of Neurology, University of Minnesota Hospitals, Minneapolis, Minn., USA
          Article
          107354 Dement Geriatr Cogn Disord 1993;4:132–136
          10.1159/000107354
          8401780
          © 1993 S. Karger AG, Basel

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          Pages: 5
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