This study investigates the heat and mass transfer in an unsteady squeezing flow between parallel plates under the influence of novel variable diffusivity. In most of the literature, it is believed that the thermophysical properties of the fluid are unchanged. However, this present study bridges this gap by assuming that viscosity, conductivity, and diffusivity are all temperature‐dependent. Physically, an appropriate analysis of thermophysical variables in such a system is required to achieve the best performance for effective heat and mass transfer processes. The equations controlled were first nondimensional and then simplified by a similarity transformation to ordinary nonlinear differential equations. The present study provides a fast convergent method on finite parallel plates, namely, the optimal homotopy analysis method (OHAM) and spectral collocation method (SCM) are used to analyze the fluid flow, heat, and mass transport. The graphical and table understanding is given via an error table and flow behavior of physical parameters. The result reveals that the SCM is more accurate than OHAM. However, the method employed in this paper offers excellent convergence solutions with good accuracy. The solution convergence is also discussed. In this type of problem, squeeze numbers play an important role and the rise in the squeezing parameter increases the fluid temperature.