Effect of Ethanol on the Metabolism of the Myocardium and its Relationship to Development of Alcoholic Myocardiopathy

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Abstract

The effect of ethanol on the metabolism of the heart muscle was studied in two series of experiments in the rat. In an acute model, a single injection of 250 mg ethanol/l00 g body weight was given intraperitoneally. Blood glucose, lactate, NEFA, and myocardial glycogen content were analyzed at 15, 30, and 60 min. All these parameters increased when measured 15 and 30 min after the ethanol injection, but they all returned to normal levels at 60 min. A model of chronic alcohol intake was investigated for 10 weeks. The same dose of ethanol was injected daily to the experimental animals whereas the control rats received an isocaloric dose of glucose. Chronic administration of ethanol caused changes not only in the glycolytic cycle of the myocardium (diminished glycolytic activity), but also in the oxidative phosphorylation of myocardial mitochondria (decrease of homogenate and mitochondria respiration as well as of respiratory control ratio of isolated mitchondria).

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Journal

Journal ID (publisher-id): CRD

Journal ID (nlm-ta): Cardiology

Journal ID (doi): 10.1159/issn.0008-6312

Title: Cardiology

Publisher: S. Karger AG

ISSN (Print): 0008-6312

ISSN (Electronic): 1421-9751

Publication date Subscription-year: 1973

Publication date (Print): 1973

Publication date (Electronic): 29 October 2008

Volume: 58

Issue: 5

Pages: 290-297

Affiliations

Third Medical Clinic and Research Laboratory for Biochemical Pharmacology, Comenius University, Bratislava-Kramáre

Article

Publisher ID: 169644 Other ID: Cardiology 1973;58:290–297

DOI: 10.1159/000169644

PubMed ID: 4799760

SO-VID: 8a7f3d6c-91ad-4705-9db2-7c1f919903b9

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Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

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Pages: 8

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