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      Effect of Ethanol on the Metabolism of the Myocardium and its Relationship to Development of Alcoholic Myocardiopathy

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          Abstract

          The effect of ethanol on the metabolism of the heart muscle was studied in two series of experiments in the rat. In an acute model, a single injection of 250 mg ethanol/l00 g body weight was given intraperitoneally. Blood glucose, lactate, NEFA, and myocardial glycogen content were analyzed at 15, 30, and 60 min. All these parameters increased when measured 15 and 30 min after the ethanol injection, but they all returned to normal levels at 60 min. A model of chronic alcohol intake was investigated for 10 weeks. The same dose of ethanol was injected daily to the experimental animals whereas the control rats received an isocaloric dose of glucose. Chronic administration of ethanol caused changes not only in the glycolytic cycle of the myocardium (diminished glycolytic activity), but also in the oxidative phosphorylation of myocardial mitochondria (decrease of homogenate and mitochondria respiration as well as of respiratory control ratio of isolated mitchondria).

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          Author and article information

          Journal
          CRD
          Cardiology
          10.1159/issn.0008-6312
          Cardiology
          S. Karger AG
          0008-6312
          1421-9751
          1973
          1973
          29 October 2008
          : 58
          : 5
          : 290-297
          Affiliations
          Third Medical Clinic and Research Laboratory for Biochemical Pharmacology, Comenius University, Bratislava-Kramáre
          Article
          169644 Cardiology 1973;58:290–297
          10.1159/000169644
          4799760
          © 1973 S. Karger AG, Basel

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          Pages: 8
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