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Abstract
Oral squamous cell carcinoma (OSCC) is a well-known malignancy that accounts for more
than 90% of all oral cancers. In this article we will perform a brief review of its
clinical characteristics and the differential diagnosis. Regarding symptoms, pain
is the most frequent presentation and the tongue and the floor of the mouth have the
highest occurrence. OSCC in its initial stages shows an erytholeukoplastic area without
symptoms but in advanced stages there are ulcers and lumps with irregular margins
which are rigid to touch. The different diagnosis should be established with other
oral malignant diseases such as lymphomas, sarcomas and metastasis, which have rapid
growth rates as opposed to the typical OSCC.
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