Effect of a single dose of the interleukin-6 receptor antagonist tocilizumab on inflammation and troponin T release in patients with non-ST-elevation myocardial infarction: a double-blind, randomized, placebo-controlled phase 2 trial.

There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

Abstract

Interleukin-6 (IL-6) contributes to atherosclerotic plaque destabilization and is involved in myocardial injury during ischaemia-reperfusion. Interleukin-6 is therefore a potential therapeutic target in myocardial infarction (MI). We hypothesized that the IL-6 receptor antagonist tocilizumab would attenuate inflammation, and secondarily reduce troponin T (TnT) release in non-ST-elevation MI (NSTEMI).

Related collections

Author and article information

Journal

Journal ID (iso-abbrev): Eur. Heart J.

Title: European heart journal

Publisher: Oxford University Press (OUP)

ISSN (Electronic): 1522-9645

ISSN (Print): 0195-668X

Publication date (Electronic): Aug 07 2016

Volume: 37

Issue: 30

Affiliations

[1 ] Clinic of Cardiology, St Olavs Hospital, Trondheim, Norway Department of Circulation and Medical Imaging, Norwegian University of Science and Technology, Trondheim, Norway ola.kleveland@ntnu.no.

[2 ] Department of Cardiology, Oslo University Hospital Rikshospitalet, Oslo, Norway Institute of Clinical Medicine, University of Oslo, Oslo, Norway.

[3 ] Department of Cardiology, Oslo University Hospital Rikshospitalet, Oslo, Norway Research Institute of Internal Medicine, Oslo University Hospital Rikshospitalet, Oslo, Norway Institute of Clinical Medicine, University of Oslo, Oslo, Norway.

[4 ] Research Institute of Internal Medicine, Oslo University Hospital Rikshospitalet, Oslo, Norway Institute of Clinical Medicine, University of Oslo, Oslo, Norway K.G. Jebsen Centre of Inflammatory Research, University of Oslo, Oslo, Norway K.G. Jebsen Cardiac Research Centre, University of Oslo, Oslo, Norway.

[5 ] Department of Cardiology, Oslo University Hospital Rikshospitalet, Oslo, Norway K.G. Jebsen Cardiac Research Centre, University of Oslo, Oslo, Norway.

[6 ] Clinic of Cardiology, St Olavs Hospital, Trondheim, Norway Department of Circulation and Medical Imaging, Norwegian University of Science and Technology, Trondheim, Norway.

[7 ] Research Institute of Internal Medicine, Oslo University Hospital Rikshospitalet, Oslo, Norway Institute of Clinical Medicine, University of Oslo, Oslo, Norway.

[8 ] Department of Cardiology, Oslo University Hospital Rikshospitalet, Oslo, Norway.

[9 ] Centre of Molecular Inflammation Research, Department of Cancer Research and Molecular Medicine, Norwegian University of Science and Technology, Trondheim, Norway.

[10 ] Department of Circulation and Medical Imaging, Norwegian University of Science and Technology, Trondheim, Norway Department of Cardiology, Oslo University Hospital Rikshospitalet, Oslo, Norway.

[11 ] Research Institute of Internal Medicine, Oslo University Hospital Rikshospitalet, Oslo, Norway Institute of Clinical Medicine, University of Oslo, Oslo, Norway K.G. Jebsen Centre of Inflammatory Research, University of Oslo, Oslo, Norway.

[12 ] Department of Cardiology, Oslo University Hospital Rikshospitalet, Oslo, Norway Institute of Clinical Medicine, University of Oslo, Oslo, Norway K.G. Jebsen Cardiac Research Centre, University of Oslo, Oslo, Norway Centre for Heart Failure Research, University of Oslo, Oslo, Norway.

Article

Publisher Item ID: ehw171

DOI: 10.1093/eurheartj/ehw171

PubMed ID: 27161611

SO-VID: 8cb9714a-7d89-4d7c-b9b5-79b2ca6128c8

History

Keywords: Acute coronary syndromes,Inflammation,Interleukin-6,Myocardial infarction,Tocilizumab

Data availability:

Keywords: Acute coronary syndromes, Inflammation, Interleukin-6, Myocardial infarction, Tocilizumab

Effect of a single dose of the interleukin-6 receptor antagonist tocilizumab on inflammation and troponin T release in patients with non-ST-elevation myocardial infarction: a double-blind, randomized, placebo-controlled phase 2 trial.

Read this article at

Abstract

Related collections

Karger: Cardiovascular System

Author and article information

Journal

Affiliations

Article

History

Comments

Comment on this article

Similar content 2

Cited by 138