+1 Recommend
1 collections
      • Record: found
      • Abstract: found
      • Article: found

      Alterations in Calcium Transport and Binding by the Plasma Membrane of Mesenteric Arteries from Spontaneously Hypertensive Rats


      Read this article at

          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.


          The effect of Sr++, Ba++ and Mn++ on calcium uptake by a plasma membrane-enriched fraction from mesenteric arteries of spontaneously hypertensive rats (SHR) was studied to determine what alterations in divalent cation interactions are associated with hypertension. <sup>45</sup>Ca++ uptake in the presence of ATP by this fraction from SHR was significantly greater than that of normotensive rats (NWR). This <sup>45</sup>Ca++ uptake by these fractions from both types of rat could be reduced by Ba++, Sr++ and nonradioactive Ca++, but not by Mn++; the ability of these cations to compete with <sup>45</sup>Ca++ was in the following order Ca++ > Sr++ > Ba++. In contrast, <sup>45</sup>Ca++ uptake in the absence of ATP by this subcellular fraction from SHR was significantly less than that of NWR, and this passive <sup>45</sup>Ca++ binding could be displaced by Mn++ in addition to the other cations. Both qualitative and quantitative differences were found between SHR and NWR in this study of the effects of cations on calcium uptake by arterial plasma membrane. These results suggest that 1 This investigation was supported by the Alberta Heart Foundation and the Medical Research Council of Canada. 2 In this paper, calcium uptake is used operationally to describe all processes (binding, transport, etc.) leading to calcium accumulation, and calcium transport refers only to the process whereby calcium is transported actively across the vesicle membrane. 3 Dr. Janis was a Fellow of the Canadian Heart Foundation, and his present address is Department of Physiology, Northwestern University Medical School, Chicago, IL 60611 (USA). the plasma membrane of SHR arteries has calcium-binding and -transport properties that are different from those of NWR. However, there is not a complete correlation between the reported effects of the cations on contraction of other arteries in hypertension and on calcium uptake by membranes of SHR and NWR.

          Related collections

          Author and article information

          J Vasc Res
          Journal of Vascular Research
          S. Karger AG
          18 September 2008
          : 14
          : 1
          : 55-64
          Department of Pharmacology, University of Alberta, Edmonton, Alta.
          158114 Blood Vessels 1977;14:55–64
          © 1977 S. Karger AG, Basel

          Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

          Page count
          Pages: 10


          Comment on this article