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      Glycerol Induced Hemoglobinuric Acute Renal Failure in the Rat

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      Nephron

      S. Karger AG

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          Abstract

          Hemoglobinuric acute renal failure occurs consistently in rats deprived of water for 24 h and injected with 50% glycerol solution (10 ml/kg) intramuscularly. Severe azotemia developed in 33% of non-dehydrated rats receiving glycerol but 44% were not azotemic, thus permitting a study of the factors which predispose to the development of acute renal failure. There was no necessary correlation between urine volume, urine osmolality, or plasma volume before injection and the development of oliguric acute renal failure, nor was the urine pH during hemoglobinuria correlated with the subsequent severity of azotemia. Plasma volume depletion was the only major difference detected between dehydrated rats which universally developed severe acute renal failure and non-dehydrated rats which were frequently spared. Small differences in plasma volume did not appear to alter the severity of renal involvement in non-dehydrated rats, however.

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          Author and article information

          Journal
          NEF
          Nephron
          10.1159/issn.1660-8151
          Nephron
          S. Karger AG
          1660-8151
          2235-3186
          1967
          1967
          26 November 2008
          : 4
          : 5
          : 276-297
          Affiliations
          Departments of Medicine, Peter Bent Brigham Hospital and Harvard Medical School, Boston, Mass
          Article
          179588 Nephron 1967;4:276–297
          10.1159/000179588
          6064791
          © 1967 S. Karger AG, Basel

          Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

          Page count
          Pages: 22
          Categories
          Paper

          Cardiovascular Medicine, Nephrology

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