For Publishers
DiscoveryMetadataPeer reviewHostingPublishing
For Researchers
JoinPublishReviewCollect
Register
Blog
About
Search
Advanced search
My ScienceOpen
Search
For Publishers
For Researchers
Blog
About
Inviting an author to review:
On-line hemodiafiltration reduces the proinflammatory CD14+CD16+ monocyte-derived dendritic cells: A prospective, crossover study.
Find an author and click ‘Invite to review selected article’ near their name.
Search for authorsSearch for similar articles
2
views
71
references
 Top references
cited by
5
    
0 reviews
 Review
0
comments
 Comment
0
recommends
+1 Recommend
0 collections
    0
    shares
      28
      similar
       All similar
      • Record: found
      • Abstract: found
      • Article: found
      Is Open Access

      Recent Progress in Metal-Free Direct Synthesis of Imidazo[1,2- a]pyridines

      review-article
      Author(s):
      Publication date (Electronic):
      Journal: ACS Omega
      Publisher: American Chemical Society

      Read this article at

      ScienceOpenPublisherPMC
      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          This Mini-Review highlights the most effective protocols for metal-free direct synthesis of imidazo[1,2- a]pyridines, crucial target products and key intermediates, developed in the past decade. The emphases is given on the ecological impact of the methods and on the mechanistic aspects as well. The procedures efficiently applied in the preparation of important drugs and promising drug candidates are also underlined.

          Related collections

          Most cited references71

          • Record: found
          • Abstract: found
          • Article: not found

          Recent progress in the pharmacology of imidazo[1,2-a]pyridines.

          Cécile Enguehard-Gueiffier, Alain Gueiffier (2007)
          Imidazo[1,2-a]pyridine is a bicyclic system with a bridgehead nitrogen atom, of growing interest in medicinal chemistry. The paper deals with the recent progress realised in the comprehension of the pharmacological properties of this scaffold. From the many imidazo[1,2-a]pyridine analogues described in the literature, those discussed herein will be presented in three parts concerning first the enzyme inhibitors, then the receptor ligands and finally the anti-infectious agents.
          Article 0 comments Cited 56 times – based on 0 reviews     Review now
            Bookmark
            • Record: found
            • Abstract: found
            • Article: not found

            Synthesis of imidazo[1,2-a]pyridines: a decade update

            Avik Bagdi, Sougata Santra, Kamarul Monir … (2015)
            Here we describe the various strategies for the synthesis of imidazo[1,2- a ]pyridines. Imidazopyridine is one of the important fused bicyclic 5–6 heterocycles and it is recognized as a “drug prejudice” scaffold due to its wide range of applications in medicinal chemistry. This moiety is also useful in material science because of its structural character. Synthesis of this moiety from the easily available chemicals is desirable due to its tremendous use in the various branches of chemistry. Here we report a review on the synthesis of this scaffold employing different strategies such as condensation, multicomponent reactions, oxidative coupling, tandem reactions, aminooxygenation, and hydroamination reactions.
            Article 0 comments Cited 52 times – based on 0 reviews     Review now
              Bookmark
              • Record: found
              • Abstract: found
              • Article: not found

              The Groebke-Blackburn-Bienaymé Reaction : The Groebke-Blackburn-Bienaymé Reaction

              André Boltjes, Alexander Dömling (2019)
              Imidazo[1,2-a]pyridine is a well-known scaffold in many marketed drugs, such as Zolpidem, Minodronic acid, Miroprofen and DS-1 and it also serves as a broadly applied pharmacophore in drug discovery. The scaffold revoked a wave of interest when Groebke, Blackburn and Bienaymé reported independently a new three component reaction resulting in compounds with the imidazo[1,2-a]-heterocycles as a core structure. During the course of two decades the Groebke Blackburn Bienaymé (GBB-3CR) reaction has emerged as a very important multicomponent reaction (MCR), resulting in over a hundred patents and a great number of publications in various fields of interest. Now two compounds derived from GBB-3CR chemistry received FDA approval. To celebrate the first 20 years of GBB-chemistry, we present an overview of the chemistry of the GBB-3CR, including an analysis of each of the three starting material classes, solvents and catalysts. Additionally, a list of patents and their applications and a more in-depth summary of the biological targets that were addressed, including structural biology analysis, is given.
              Article 0 comments Cited 22 times – based on 0 reviews     Review now
                Bookmark
                All references

                Author and article information

                Journal
                Journal ID (nlm-ta): ACS Omega
                Journal ID (iso-abbrev): ACS Omega
                Journal ID (publisher-id): ao
                Journal ID (coden): acsodf
                Title: ACS Omega
                Publisher: American Chemical Society
                ISSN (Electronic): 2470-1343
                Publication date (Electronic): 14 December 2021
                Publication date Collection: 28 December 2021
                Volume: 6
                Issue: 51
                Pages: 35173-35185
                Affiliations
                [1]Institute of Organic Chemistry with Centre of Phytochemistry, Bulgarian Academy of Sciences , Acad. G. Bonchev str., bl. 9, 1113 Sofia, Bulgaria
                Author notes
                [* ]Email: vanya.kurteva@ 123456orgchm.bas.bg . Phone: +359 878940364.
                Author information
                https://orcid.org/0000-0001-8703-0066
                Article
                DOI: 10.1021/acsomega.1c03476
                PMC ID: 8717391
                PubMed ID: 34984250
                SO-VID: 8fb6ae8e-782d-4e02-9b6f-8f4ab46f0a02
                Copyright © © 2021 The Author. Published by American Chemical Society
                License:

                Permits non-commercial access and re-use, provided that author attribution and integrity are maintained; but does not permit creation of adaptations or other derivative works ( https://creativecommons.org/licenses/by-nc-nd/4.0/).

                History
                Date received : 02 July 2021
                Date accepted : 30 November 2021
                Categories
                Subject: Mini-Review
                Custom metadata
                document-id-old-9 ao1c03476
                document-id-new-14 ao1c03476
                ccc-price

                Data availability:

                Comments

                Comment on this article

                scite_

                Similar content28

                See all similar

                Cited by5

                See all cited by

                Most referenced authors725

                See all reference authors