270
views
0
recommends
+1 Recommend
0 collections
    23
    shares
      • Record: found
      • Abstract: not found
      • Article: not found

      The basics of epithelial-mesenchymal transition

      ,
      Journal of Clinical Investigation
      American Society for Clinical Investigation

      Read this article at

      ScienceOpenPublisherPMC
      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          The origins of the mesenchymal cells participating in tissue repair and pathological processes, notably tissue fibrosis, tumor invasiveness, and metastasis, are poorly understood. However, emerging evidence suggests that epithelial-mesenchymal transitions (EMTs) represent one important source of these cells. As we discuss here, processes similar to the EMTs associated with embryo implantation, embryogenesis, and organ development are appropriated and subverted by chronically inflamed tissues and neoplasias. The identification of the signaling pathways that lead to activation of EMT programs during these disease processes is providing new insights into the plasticity of cellular phenotypes and possible therapeutic interventions.

          Related collections

          Author and article information

          Journal
          Journal of Clinical Investigation
          J. Clin. Invest.
          American Society for Clinical Investigation
          0021-9738
          June 1 2009
          June 1 2009
          : 119
          : 6
          : 1420-1428
          Article
          10.1172/JCI39104
          2689101
          19487818
          90685290-c556-41f0-aae5-89f191440929
          © 2009
          Product
          Self URI (article page): http://www.jci.org/articles/view/39104

          Comments

          Comment on this article