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      Analbuminemic Nagase Rats: Blood Pressure Response to Dietary Salt Challenge

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          Background: The role of albumin on blood pressure response to different salt challenges is not known. Therefore, we studied the blood pressure response of analbuminemic Nagase rats (NAR) to different salt challenges. 11β-Hydroxysteroid dehydrogenase type 2 (11β-HSD2), the enzyme regulating the glucocorticoid access to the mineralocorticoid receptor, an enzyme that is decreased in humans with salt sensitive hypertension and other diseases with abnormal renal salt retention, was assessed during salt challenges. Methods: Blood pressure was measured continuously by an intra-arterial catheter and a telemetry system in NAR (n = 8). NAR were set successively for 7 days on a normal (0.45% NaCl), high (8% NaCl), low (0.1% NaCl) and normal salt diet again, to assess salt related response in mean systolic (SBP) and diastolic blood pressure (DBP). 11β-HSD2activity was assessed by measuring the urinary (THB + 5α-THB)/THA ratio with gas chromatography – mass spectrometry. Results: Mean SBP and DBP increased with high salt intake (normal salt vs. high salt: SBP: 114 ± 1 vs.119 ± 3 mm Hg, p < 0.01; DBP: 84 ± 1 vs. 88 ± 3 mm Hg; n = 8; p < 0.01). Urinary (THB +5α-THB)/THA ratio increased during the high-salt period when compared to the normal-salt period (high salt vs. normal salt: 0.52 ± 0.10 vs. 0.37 ± 0.07; p = 0.05) indicating decreased 11β-HSD2activity. Conclusion: Analbuminemic Nagase rats express increased blood pressure and reduced 11β-HSD2 activity in response to a high-salt diet.

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          Albumin-deficient rat mutant.

          An analbuminemic colony was established from Sprague-Dawley rats. Analbuminemia was inherited as an autosomal recessive trait. The rates of growth and reproduction of the mutant rats were no different from those of normal rats. Biochemically, the mutant was characterized by an extraordinarily low serum albumin content and a hyperlipidemia. Total serum protein in the mutant rat was similar to that of control Sprague-Dawley rats, with increased globulin. Serum cholesterol was inversely correlated with a decrease in albumin; the correlation coefficient for ablumin was --.92. These mutant rats may serve as a model of human familial analbuminemia and may also be useful in elucidating the functional roles of albumin.
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            Profiling steroid hormones and urinary steroids

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              Renal determinants of the salt sensitivity of blood pressure.


                Author and article information

                Nephron Physiol
                Nephron Physiology
                S. Karger AG
                September 2006
                28 September 2006
                : 104
                : 2
                : p81-p86
                Clinic and Policlinic of Nephrology and Hypertension, University Hospital Inselspital, Berne, Switzerland
                94002 Nephron Physiol 2006;104:p81–p86
                © 2006 S. Karger AG, Basel

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