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      Analbuminemic Nagase Rats: Blood Pressure Response to Dietary Salt Challenge

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          Abstract

          Background: The role of albumin on blood pressure response to different salt challenges is not known. Therefore, we studied the blood pressure response of analbuminemic Nagase rats (NAR) to different salt challenges. 11β-Hydroxysteroid dehydrogenase type 2 (11β-HSD2), the enzyme regulating the glucocorticoid access to the mineralocorticoid receptor, an enzyme that is decreased in humans with salt sensitive hypertension and other diseases with abnormal renal salt retention, was assessed during salt challenges. Methods: Blood pressure was measured continuously by an intra-arterial catheter and a telemetry system in NAR (n = 8). NAR were set successively for 7 days on a normal (0.45% NaCl), high (8% NaCl), low (0.1% NaCl) and normal salt diet again, to assess salt related response in mean systolic (SBP) and diastolic blood pressure (DBP). 11β-HSD2activity was assessed by measuring the urinary (THB + 5α-THB)/THA ratio with gas chromatography – mass spectrometry. Results: Mean SBP and DBP increased with high salt intake (normal salt vs. high salt: SBP: 114 ± 1 vs.119 ± 3 mm Hg, p < 0.01; DBP: 84 ± 1 vs. 88 ± 3 mm Hg; n = 8; p < 0.01). Urinary (THB +5α-THB)/THA ratio increased during the high-salt period when compared to the normal-salt period (high salt vs. normal salt: 0.52 ± 0.10 vs. 0.37 ± 0.07; p = 0.05) indicating decreased 11β-HSD2activity. Conclusion: Analbuminemic Nagase rats express increased blood pressure and reduced 11β-HSD2 activity in response to a high-salt diet.

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          Most cited references 9

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          Albumin-deficient rat mutant.

          An analbuminemic colony was established from Sprague-Dawley rats. Analbuminemia was inherited as an autosomal recessive trait. The rates of growth and reproduction of the mutant rats were no different from those of normal rats. Biochemically, the mutant was characterized by an extraordinarily low serum albumin content and a hyperlipidemia. Total serum protein in the mutant rat was similar to that of control Sprague-Dawley rats, with increased globulin. Serum cholesterol was inversely correlated with a decrease in albumin; the correlation coefficient for ablumin was --.92. These mutant rats may serve as a model of human familial analbuminemia and may also be useful in elucidating the functional roles of albumin.
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            Profiling steroid hormones and urinary steroids

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              Renal determinants of the salt sensitivity of blood pressure.

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                Author and article information

                Journal
                NEP
                Nephron Physiol
                10.1159/issn.1660-2137
                Nephron Physiology
                S. Karger AG
                1660-2137
                2006
                September 2006
                28 September 2006
                : 104
                : 2
                : p81-p86
                Affiliations
                Clinic and Policlinic of Nephrology and Hypertension, University Hospital Inselspital, Berne, Switzerland
                Article
                94002 Nephron Physiol 2006;104:p81–p86
                10.1159/000094002
                16785748
                © 2006 S. Karger AG, Basel

                Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

                Page count
                Figures: 6, References: 12, Pages: 1
                Product
                Self URI (application/pdf): https://www.karger.com/Article/Pdf/94002
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