A chimeric Cfh transgene leads to increased retinal oxidative stress, inflammation, and accumulation of activated subretinal microglia in mice.

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Abstract

Variants of complement factor H (Cfh) affecting short consensus repeats (SCRs) 6 to 8 increase the risk of age-related macular degeneration. Our aim was to explore the effect of expressing a Cfh variant on the in vivo susceptibility of the retina and RPE to oxidative stress and inflammation, using chimeric Cfh transgenic mice (chCfhTg).

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Journal

Journal ID (iso-abbrev): Invest. Ophthalmol. Vis. Sci.

Title: Investigative ophthalmology & visual science

ISSN (Electronic): 1552-5783

ISSN (Print): 0146-0404

Publication date (Electronic): Jun 2015

Volume: 56

Issue: 6

Affiliations

[1 ] Department of Ophthalmology UT Southwestern Medical Center, Dallas, Texas, United States.

[2 ] Department of Ophthalmology UT Southwestern Medical Center, Dallas, Texas, United States 2Department of Ophthalmology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, People's Republic of China.

Article

Publisher Item ID: 2300845

DOI: 10.1167/iovs.14-16089

PMC ID: 4464010

PubMed ID: 26030099

SO-VID: 91c7fc4d-39e0-458e-bf09-63d31f26eaec

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