- Record: found
- Abstract: found
- Article: not found
Genetics and Hemostatic Potential in Persons with Mild to Moderate Hemophilia A with a Discrepancy between One-Stage and Chromogenic FVIII Assays.
Annelie Strålfors
1
,
2 ,
Danijela Mikovic
3 ,
David Schmidt
4
,
5 ,
Liselotte Onelöv
2 ,
Nida Mahmoud Hourani Soutari
1
,
2 ,
Maria Berndtson
1
,
2 ,
Roza Chaireti
1
,
4 ,
Margareta Holmström
4
,
5 ,
Jovan P Antovic
1
,
2 ,
Maria Bruzelius
1
,
4
,
5
Jan 2021
There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.
Abstract
Factor VIII (FVIII) activity (FVIII:C) can be measured by different methods including one-stage clotting assays (OSAs) and chromogenic assays (CSAs). Discrepancy between FVIII:C assays is known and associated with genetic variations causing mild and moderate hemophilia A (HA). We aimed to study the discrepancy phenomenon and to identify associated genetic alterations. Further, we investigated if hemostatic global assays could discriminate the group with discrepant FVIII:C from them.