[1
]Channing Division of Network Medicine, Brigham and
Women’s Hospital, Boston, MA, USA
[2
]Department of Medicine, Faculty of Medicine Siriraj
Hospital, Mahidol University, Bangkok, Thailand
[3
]Genetics and Aging Research Unit, Department of Neurology,
Massachusetts General Hospital, Boston, MA, USA
[4
]Institut universitaire de cardiologie et de pneumologie de
Québec, Québec, Canada
[5
]Genetic Epidemiology Group, Department of Health Sciences,
University of Leicester, Leicester, UK
[6
]Cardiovascular Health Research Unit, University of
Washington, Seattle, WA, USA
[7
]Department of Medicine, University of Washington, Seattle,
WA, USA
[8
]Department of Biostatistics, University of Washington,
Seattle, WA, USA
[9
]Seoul National University College of Medicine, SMG-SNU
Boramae Medical Center, Seoul, South Korea
[10
]Epidemiology Branch, National Institute of Environmental
Health Sciences, National Institutes of Health, Department of Health and Human
Services, Research Triangle Park, NC, USA
[11
]Department of Neurology, Boston University School of
Medicine, Boston, MA, USA
[12
]Department of Medicine, University of Arizona, Tucson,
AZ
[13
]The University of British Columbia Center for Heart Lung
Innovation, St Paul’s Hospital, Vancouver, BC, Canada
[14
]Department of Clinical Science, University of Bergen,
Bergen, Norway
[15
]Department of Medicine, College of Physicians and
Surgeons and Department of Epidemiology, Mailman School of Public Health, Columbia
University, New York, NY, USA
[16
]Department of Epidemiology, Johns Hopkins University
Bloomberg School of Public Health, Baltimore, MD, USA
[17
]Lovelace Respiratory Research Institute, Albuquerque, NM,
USA
[18
]Department of Epidemiology, Erasmus Medical Center,
Rotterdam, the Netherlands
[19
]Department of Respiratory Medicine, Ghent University
Hospital, Ghent, Belgium
[20
]Department of Respiratory Medicine, Erasmus Medical
Center, Rotterdam, the Netherlands
[21
]Department of Medicine, Division of Pulmonary and
Critical Care Medicine, National Jewish Health, Denver, CO, USA
[22
]University of Groningen, University Medical Center
Groningen, Department of Epidemiology, Groningen, the Netherlands
[23
]University of Groningen, University Medical Center
Groningen, Groningen Research Institute for Asthma and COPD (GRIAC), Groningen, the
Netherlands
[24
]Division of Pulmonary and Critical Care Medicine, Brigham
and Women’s Hospital, Boston, MA, USA
[25
]Center for Genes, Environment and Health, National Jewish
Health, Denver, CO, USA
[26
]Department of Biostatistics and Informatics, University
of Colorado Denver, Aurora, CO, USA
[27
]Computational Medicine Core, Center for Lung Biology, UW
Medicine Sleep Center, Department of Medicine, University of Washington, Seattle,
WA, USA
[28
]Division of Respiratory Medicine, Queen’s Medical
Centre, University of Nottingham, Nottingham, UK
[29
]National Institute for Health Research Nottingham
Biomedical Research Centre, Nottingham, UK
[30
]Department of Epidemiology, University of Colorado
Anschutz Medical Campus, Aurora, CO, USA
[31
]Department of Internal Medicine and Environmental Health
Center, School of Medicine, Kangwon National University, Chuncheon, South
Korea
[32
]UCL Respiratory, University College London, London,
UK
[33
]The National Heart, Lung, and Blood Institute’s
Framingham Heart Study, Framingham, MA, USA
[34
]Pulmonary Center, Department of Medicine, Boston
University School of Medicine, Boston, MA, USA
[35
]Pulmonary, Critical Care, Sleep and Allergy Division,
Department of Internal Medicine, University of Nebraska Medical Center, Omaha, NE,
USA
[36
]Clinical Discovery Unit, AstraZeneca, Cambridge, UK
[37
]Department of Medicine, School of Medicine, University of
Colorado Denver, Aurora, CO, USA
[38
]Department of Immunology, School of Medicine, University
of Colorado Denver, Aurora, CO, USA
[39
]2nd Department of Respiratory Medicine, Institute of
Tuberculosis and Lung Diseases, Warsaw, Poland
[40
]VA Boston Healthcare System and Department of Medicine,
Boston University School of Medicine, Boston, MA, USA
[41
]Population Health Research Institute, St. George’s
University of London, London, UK
[42
]GSK R&D, Collegeville, PA, USA
[43
]School of Biological Sciences, University of Manchester,
Manchester, UK
[44
]Division of Pulmonary and Critical Care Medicine,
Department of Internal Medicine, Seoul National University College of Medicine,
Seoul, South Korea
[45
]Department of Molecular Medicine, Laval University,
Québec, Canada
[46
]Center for Public Health Genomics, University of
Virginia, Charlottesville, VA, USA
[47
]Department of Public Health Sciences, University of
Virginia, Charlottesville, VA, USA
[48
]Department of Bioanalysis, Ghent University, Ghent,
Belgium
[49
]National Institute for Health Research, Leicester
Respiratory Biomedical Research Centre, Glenfield Hospital, Leicester, UK
[50
]A full list of authors appears at the end of the
article
[51
]These authors contributed equally
[52
]These authors jointly supervised the work