Journal ID (nlm-ta): PLoS One
Journal ID (iso-abbrev): PLoS ONE
Journal ID (publisher-id): plos
Journal ID (pmc): plosone
Title:
PLoS ONE
Publisher:
Public Library of Science
(San Francisco, CA USA
)
ISSN
(Electronic):
1932-6203
Publication date
(Electronic):
20
April
2017
Publication date Collection: 2017
Volume: 12
Issue: 4
Electronic Location Identifier: e0175642
Affiliations
[1
]MRC Laboratory of Molecular Biology, Cambridge, United Kingdom
[2
]Membrane Protein Structure Function Unit, National Institute of Neurological Disorders
and Stroke, National Institutes of Health, Department of Health and Human Services,
Rockville, United States of America
Indian Institute of Technology Kanpur, INDIA
Author notes
Competing Interests: CGT is a consultant, shareholder and member of the Scientific Advisory Board of Heptares
Therapeutics. This does not alter our adherence to PLOS ONE policies on sharing data
and materials. BC was also funded by a grant from Heptares Therapeutics.
-
Conceptualization: RN BC CGT.
-
Formal analysis: RN BC Singhal A. Strege CFW HD.
-
Funding acquisition: CGT RG.
-
Investigation: RN BC A. Singhal A. Strege CFW HD.
-
-
Project administration: CGT RG.
-
-
-
Validation: RN BC A. Singhal A. Strege CFW HD RG CGT.
-
-
Writing – original draft: RN CGT.
-
Writing – review & editing: RN BC A. Singhal RG CGT.
[¤]
Current address: Warwick Integrative Synthetic Biology Centre, School of Life Sciences,
Gibbet Hill Campus, University of Warwick, Warwick, United Kingdom
Author information
Article
Publisher ID:
PONE-D-17-04316
DOI: 10.1371/journal.pone.0175642
PMC ID: 5398546
PubMed ID: 28426733
SO-VID: 945a0d8a-94de-4eca-b212-e41cc09227a1
License:
This is an open access article, free of all copyright, and may be freely reproduced,
distributed, transmitted, modified, built upon, or otherwise used by anyone for any
lawful purpose. The work is made available under the
Creative Commons CC0 public domain dedication.
Funded by: funder-id http://dx.doi.org/10.13039/501100000781, European Research Council;
Award ID: 339995
Award Recipient
:
ORCID: http://orcid.org/0000-0002-2008-9183
Christopher G. Tate
Funded by: funder-id http://dx.doi.org/10.13039/501100000265, Medical Research Council;
Award ID: MC_U105197215
Award Recipient
:
ORCID: http://orcid.org/0000-0002-2008-9183
Christopher G. Tate
Funded by: Heptares Therapeutics
Award Recipient
:
ORCID: http://orcid.org/0000-0002-2008-9183
Christopher G. Tate
Funded by: funder-id http://dx.doi.org/10.13039/100000065, National Institute of Neurological Disorders and Stroke;
Award ID: ZIA NS003016-11
Award Recipient
:
Reinhard Grisshammer
This research was supported by the European Research Council (EMPSI 339995; R.N.,
A.S., C.G.T.), Heptares Therapeutics (B.C., C.G.T.), the Medical Research Council
(MC_U105197215; A.S., P.E., C.G.T.) and the Intramural Research Program of the National
Institutes of Health, National Institute of Neurological Disorders and Stroke (ZIA
NS003016-11; C.F.W., H.D., R.G.). The funders had no role in study design, data collection
and analysis, decision to publish, or preparation of the manuscript.
Subject:
Research Article
Subject:
Biology and Life Sciences
Subject:
Biochemistry
Subject:
Proteins
Subject:
Transmembrane Receptors
Subject:
G Protein Coupled Receptors
Subject:
Biology and Life Sciences
Subject:
Cell Biology
Subject:
Signal Transduction
Subject:
Transmembrane Receptors
Subject:
G Protein Coupled Receptors
Subject:
Physical Sciences
Subject:
Materials Science
Subject:
Materials by Attribute
Subject:
Surfactants
Subject:
Detergents
Subject:
Research and Analysis Methods
Subject:
Chemical Characterization
Subject:
Binding Analysis
Subject:
Receptor Binding Assays
Subject:
Biology and Life Sciences
Subject:
Molecular Biology
Subject:
Macromolecular Structure Analysis
Subject:
Protein Structure
Subject:
Biology and Life Sciences
Subject:
Biochemistry
Subject:
Proteins
Subject:
Protein Structure
Subject:
Biology and Life Sciences
Subject:
Molecular Biology
Subject:
Macromolecular Structure Analysis
Subject:
Protein Structure
Subject:
Protein Structure Determination
Subject:
Biology and Life Sciences
Subject:
Biochemistry
Subject:
Proteins
Subject:
Protein Structure
Subject:
Protein Structure Determination
Subject:
Research and Analysis Methods
Subject:
Chemical Characterization
Subject:
Binding Analysis
Subject:
Earth Sciences
Subject:
Glaciology
Subject:
Ice Core
Subject:
Physical Sciences
Subject:
Chemistry
Subject:
Chemical Compounds
Subject:
Organic Compounds
Subject:
Imidazole
Subject:
Physical Sciences
Subject:
Chemistry
Subject:
Organic Chemistry
Subject:
Organic Compounds
Subject:
Imidazole