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      Polybioside, a neuroactive compound from the venom of the social wasp Polybia paulista.

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          Abstract

          Polybioside (1) was isolated from the venom of the social wasp Polybia paulista, and its structure was assigned as 3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl 3-(1H-imidazol-4-yl)propanimidate by NMR and MS protocols. The application of polybioside in rat brain, followed by the detection of c-Fos protein expression in some brain regions, indicated the compound is neuroactive in a number of brain areas. Polybioside causes convulsions in rats, even when peripherally applied.

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          Author and article information

          Journal
          J. Nat. Prod.
          Journal of natural products
          American Chemical Society (ACS)
          1520-6025
          0163-3864
          Apr 23 2010
          : 73
          : 4
          Affiliations
          [1 ] Laboratory of Structural Biology and Zoochemistry, Department of Biology/CEIS, Institute of Biosciences, São Paulo State University (UNESP), 13506-900, Rio Claro, SP, Brazil.
          Article
          10.1021/np900424t
          20158240
          95048c70-f342-4137-a155-4f447b2330c1

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