There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.
Abstract
In this study, emodin-eluting poly(lactide-co-glycolide) (PLGA) coating stents and
emodin-loaded PLGA films were prepared to explore the potential application of emodin-eluting
stent for treating cardiovascular disease. Fourier transform infrared spectra (FTIR)
showed all characteristic adsorption peaks of emodin in emodin-loaded PLGA film in
comparison to pure emodin. The balloon expansion experiment and surface morphology
observation suggested that the integrated emodin-eluting coatings were successfully
obtained on the stainless steel surfaces and the coatings had the ability to withstand
the strains imparted during balloon experiment. The drug release profile revealed
the nearly linear release curve without obvious burst release for different doses
of emodin-eluting stents. As compared with stainless steel and PLGA, in vitro platelet
adhesion and APTT (activated partial thromboplastin time) tests revealed better blood
compatibility of emodin-eluting stent. In conclusion, the results of the present study
showed that the emodin-eluting stent has a potential application for treating cardiovascular
disease.
Crown Copyright 2010. Published by Elsevier B.V. All rights reserved.