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      Incomplete Renal Tubular Acidosis: some Clinical and Physiological Features

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          Abstract

          17 patients with recurrent calcium-containing-renal calculi were studied using the short NH<sub>4</sub>CI test and one subject with ‘incomplete renal tubular acidosis’ was identified. In retrospect the only clue to this diagnosis was a fasting, morning urine pH exceeding 6.0 units. Fasting morning urine pH, which is usually less than 6.0 in subjects who acidify normally, is proposed as a simple screening test for ‘incomplete RTA’. Modified high dose NH<sub>4</sub>CI tests and Na<sub>2</sub>SO<sub>4</sub> tests were performed in this subject and other patients with either complete or incomplete distal renal tubular acidosis. These studies suggest that the ability to lower urine pH is impaired less with the incomplete than with the complete form of the disease.

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          Author and article information

          Journal
          NEF
          Nephron
          10.1159/issn.1660-8151
          Nephron
          S. Karger AG
          1660-8151
          2235-3186
          1975
          1975
          28 November 2008
          : 15
          : 2
          : 111-123
          Affiliations
          Department of Medicine, University of Vermont, Burlington, Vt.; Department of Metabolism, Walter Reed Army Institute of Research, Washington, D.C.; Department of Medicine, Medical College of Virginia, Health Sciences Division, Virginia Commonwealth University, and McGuire Veterans Administration Hospital, Richmond, Va., and the Department of Medicine, Medical University of South Carolina, Charleston, S. C.
          Article
          180502 Nephron 1975;15:111–123
          10.1159/000180502
          239357
          95e491f3-47cb-4ff2-97b2-730cea36224a
          © 1975 S. Karger AG, Basel

          Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

          History
          : 16 August 1974
          : 05 November 1974
          Page count
          Pages: 13
          Categories
          Original Paper

          Cardiovascular Medicine,Nephrology
          Renal calculi,Renal tubular acidosis,Urine acidification,Incomplete renal tubular acidosis,Urine pH

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