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      Patient specific selection of lateral wall cochlear implant electrodes based on anatomical indication ranges

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          Abstract

          Objectives

          The aim of this study was to identify anatomical indication ranges for different lateral wall cochlear implant electrodes to support surgeons in the preoperative preparation.

          Methods

          272 patients who were implanted with a FLEX 20, FLEX 24, FLEX 28, or a custom-made device (CMD) were included in this study. The cochlear duct length ( CDL) and basal cochlear diameter (length A) were measured within preoperative imaging data. The parameter A was then employed to additionally compute CDL estimates using literature approaches. Moreover, the inserted electrode length ( IEL) and insertion angle ( IA) were measured in postoperative CT data. By combining the preoperative measurements with the IA data, the covered cochlea length ( CCL) and relative cochlear coverage ( CC) were determined for each cochlea.

          Results

          The measurements of the CDL show comparable results to previous studies. While CDL measurements and estimations cover similar ranges overall, severe deviations occur in individual cases. The electrode specific IEL and CCL are fairly consistent and increase with longer electrodes, but relatively wide ranges of electrode specific CC values were found due to the additional dependence on the respective CDL. Using the correlation of IEL and CCL across electrode arrays, CDL ranges for selected arrays were developed (FLEX 24: 31.3–34.4, FLEX 28: 36.2–40.1, FLEX Soft: 40.6–44.9).

          Conclusions

          Our analysis shows that electrode specific CC varies due to the CDL variation. Preoperative measurement of the CDL allows for an individualized implant length selection yielding optimized stimulation and a reduced risk of intraoperative trauma. The CDL, as derived from preoperative CT imaging studies, can help the implant surgeon select the appropriate electrode array to maximize the patient’s outcomes.

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          Most cited references27

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          An overview of cochlear implant electrode array designs

          Cochlear implant electrode arrays are designed with specific characteristics that allow for the preservation of intra-cochlear structures during the insertion process, as well as during explantation. Straight lateral wall (LW) electrode arrays and pre-curved modiolar hugging (MH) electrode arrays are the two types that are commercially available. Although there is a third type of electrode array called the mid-scala (MS), which is positioned in the middle of the scala tympani (ST), and is usually considered as an MH type of electrode. Different lengths of straight LW electrode arrays are currently available which allow for insertion across a range of different sized cochleae; however, due to manufacturing limitations, pre-curved MH electrodes are generally only available to cover the basal turn of the cochlea, while the spiral ganglion cells are distributed in the Rosenthal's canal that extends into 1.75 turns of the cochlea. Both straight LW and pre-curved MH electrodes can cause a certain degree of intra-cochlear trauma, but pre-curved MH electrodes tend to deviate into the scala vestibuli from the scala tympani more often than the straight LW electrodes, resulting in damage to the osseous spiral lamina/spiral ligament which could initiate new bone formation and eventually affect the cochlear implant users' hearing performance. Structural damage to the cochlea could also affect the vestibular function. With pre-curved MH electrodes, higher degrees of trauma are related to the fixed curling geometry of the electrode in relation to the variable coiling pattern of individual cochleae, the orientation of the electrode contacts in relation to the modiolus wall, and how effectively the stylet was handled by the surgeon during the procedure. Wire management, metal density, and the shore hardness of the silicone elastomer all contribute to the stiffness/flexibility of the electrode. It is important to acknowledge the impact of bringing the stimulating contacts closer to the modiolus wall with an MH electrode type in terms of the resultant damage to intra-cochlear structures. The presence of malformed cochleae should be identified and appropriate electrodes should be chosen for each specific cochlea, irrespective of the cochlear implant brand. In order to utilize drug therapy, the cochlea should be free from any trauma.
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            Variational anatomy of the human cochlea: implications for cochlear implantation.

            To study variations in human cochlea anatomy with potential implications for cochlear implantation surgery. A comprehension of the anatomic variations of the human cochlea is essential for understanding the degree of surgical trauma induced by inserting various electrode arrays in cochlear implantation surgery. Variations in anatomy may also limit the potential for performing hearing preservation. We studied 73 archival, nonselected, adult, corrosion casts of human inner ears. Anatomic reference points were constructed from photographic reproductions taken at different angles, and various dimensions were assessed using planimetry. Anatomic variants with particular clinical/surgical interests were pinpointed. Results showed that the human cochlea is individually shaped, varying greatly in dimensions ("fingerprint"). The outer cochlear wall length ranged from 38.6 to 45.6 mm with a mean length of 42.0 mm. The first turn represented 53% of the total length and ranged from 20.3 to 24.3 mm. The number of quadrants varied from slightly more than 8 to 12. The facial nerve canal ran in close proximity to the upper first turn explaining facial nerve excitement during stimulation of electrodes in this region in some instances. The internal diameter (height) of the cochlear tube in the first turn varied broadly (1.6-2.6 mm), occasionally with limited space for conventional implants. The human cochlea exhibits extensive anatomic variations. These variations will influence the location of cochlear implant arrays and affect the potential of hearing preservation surgery. Our results may explain the surgeon's difficulties sometimes to insert electrode arrays even in so-called "normal" cochleae.
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              Electrode Location and Angular Insertion Depth Are Predictors of Audiologic Outcomes in Cochlear Implantation.

              1) Investigate the impact of electrode type and surgical approach on scalar electrode location; and 2) examine the relation between electrode location and postoperative audiologic performance.
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                Author and article information

                Contributors
                Role: Data curationRole: InvestigationRole: MethodologyRole: VisualizationRole: Writing – original draft
                Role: SupervisionRole: Writing – original draft
                Role: Investigation
                Role: Investigation
                Role: ResourcesRole: Supervision
                Role: ResourcesRole: Supervision
                Role: SupervisionRole: Writing – original draft
                Role: Editor
                Journal
                PLoS One
                PLoS ONE
                plos
                plosone
                PLoS ONE
                Public Library of Science (San Francisco, CA USA )
                1932-6203
                26 October 2018
                2018
                : 13
                : 10
                : e0206435
                Affiliations
                [001]Cluster of Excellence Hearing4all, Department of Otorhinolaryngology, Hannover Medical School, Hannover, Lower Saxony, Germany
                University of California Irvine, UNITED STATES
                Author notes

                Competing Interests: Company MedEl paid for one scientific congress charge, traveling and hotel costs for Max Eike Timm and Thomas Lenarz in the past (2017,2018). This does not alter our adherence to PLOS ONE policies on sharing data and materials.

                Author information
                http://orcid.org/0000-0002-6610-1950
                Article
                PONE-D-17-41283
                10.1371/journal.pone.0206435
                6203394
                30365565
                963aa0e2-67b5-42f7-8314-48181949b408
                © 2018 Timm et al

                This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

                History
                : 5 December 2017
                : 12 October 2018
                Page count
                Figures: 11, Tables: 2, Pages: 14
                Funding
                This study was supported by the German ministry for research and education (BMBF) under FKZ 13GW0160B "my-CI" and MED-EL Deutschland GmbH. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. MedEl Deutschland GmbH paid for scientific congress charge, traveling and hotel costs for Max Eike Timm and Thomas Lenarz. No other author received specific funding for this work.
                Categories
                Research Article
                Biology and Life Sciences
                Anatomy
                Head
                Ears
                Inner Ear
                Cochlea
                Medicine and Health Sciences
                Anatomy
                Head
                Ears
                Inner Ear
                Cochlea
                Biology and Life Sciences
                Bioengineering
                Biotechnology
                Medical Devices and Equipment
                Medical Implants
                Engineering and Technology
                Bioengineering
                Biotechnology
                Medical Devices and Equipment
                Medical Implants
                Medicine and Health Sciences
                Medical Devices and Equipment
                Medical Implants
                Biology and life sciences
                Anatomy
                Head
                Ears
                Organ of Corti
                Medicine and health sciences
                Anatomy
                Head
                Ears
                Organ of Corti
                Research and Analysis Methods
                Imaging Techniques
                Neuroimaging
                Computed Axial Tomography
                Biology and Life Sciences
                Neuroscience
                Neuroimaging
                Computed Axial Tomography
                Medicine and Health Sciences
                Diagnostic Medicine
                Diagnostic Radiology
                Tomography
                Computed Axial Tomography
                Research and Analysis Methods
                Imaging Techniques
                Diagnostic Radiology
                Tomography
                Computed Axial Tomography
                Medicine and Health Sciences
                Radiology and Imaging
                Diagnostic Radiology
                Tomography
                Computed Axial Tomography
                Medicine and Health Sciences
                Surgical and Invasive Medical Procedures
                Functional Electrical Stimulation
                Medicine and Health Sciences
                Surgical and Invasive Medical Procedures
                Computer and Information Sciences
                Data Acquisition
                Physical Sciences
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                Probability Theory
                Probability Distribution
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                All relevant data are within the paper and its Supporting Information files.

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